Sharon Bajda, Arturo Blazquez-Navarro, Björn Samans, Patrizia Wehler, Sviatlana Kaliszczyk, Leila Amini, Michael Schmueck‑Henneresse, Oliver Witzke, Ulf Dittmer, Timm Westhoff, Richard Viebahn, Petra Reinke, Oliver Thomusch, Christian Hugo, Sven Olek, Toralf Roch, Nina Babel
- Epstein-Barr virus (EBV) reactivation can lead to serious complications in kidney transplant patients, including post-transplant lymphoproliferative disorder (PTLD). Here, we have assessed the impact of EBV on B cell homeostasis at cellular and humoral level. In a multicenter study monitoring 540 kidney transplant patients during the first post-transplant year, EBV reactivation was detected in 109 patients. Thirteen soluble factors and B cell counts were analyzed in an \(EBV^{+}\) sub-cohort (N = 54) before, at peak and after EBV clearance and compared to a control group (N = 50). The B cell activating factor (BAFF) was significantly elevated among \(EBV^{+}\) patients. No additional soluble factors were associated with EBV. Importantly, in vitro experiments confirmed the proliferative effect of BAFF on EBV-infected B cells, simultaneously promoting EBV production. In contrast, elevated levels of BAFF in \(EBV^{+}\) patients did not lead to B cell expansion in vivo. Moreover, diminished positive inter-correlations of soluble factors and alterations of the bi-directional interplay between B cell and soluble factors were observed in \(EBV^{+}\) patients at peak and after clearance. Our data suggest that such alterations may counteract the proliferative effect of BAFF, preventing B cell expansion. The role of these alterations in lymphoma development should be analyzed in future studies.
MetadatenAuthor: | Sharon BajdaGND, Arturo Blazquez-NavarroGND, Björn SamansGND, Patrizia WehlerGND, Sviatlana KaliszczykGND, Leila AminiGND, Michael Schmueck‑HenneresseGND, Oliver WitzkeGND, Ulf DittmerGND, Timm WesthoffORCiDGND, Richard ViebahnORCiDGND, Petra ReinkeGND, Oliver ThomuschGND, Christian HugoGND, Sven OlekGND, Toralf RochORCiDGND, Nina BabelORCiDGND |
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URN: | urn:nbn:de:hbz:294-95491 |
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DOI: | https://doi.org/10.1038/s41598-020-76607-z |
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Parent Title (English): | Scientific reports |
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Publisher: | Macmillan Publishers Limited |
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Place of publication: | London |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2023/01/02 |
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Date of first Publication: | 2020/11/11 |
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Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
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Volume: | 10 |
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Issue: | Article 19594 |
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First Page: | 19594-1 |
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Last Page: | 19594-13 |
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Note: | Dieser Beitrag ist auf Grund des DEAL-Springer-Vertrages frei zugänglich. |
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Institutes/Facilities: | Marienhospital Herne, Medizinische Klinik I |
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Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
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open_access (DINI-Set): | open_access |
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Licence (English): | Creative Commons - CC BY 4.0 - Attribution 4.0 International |
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