Nonclassical vitamin D actions
- It is becoming increasingly clear that vitamin D has a broad range of actions in the human body. Besides its well-known effects on calcium/phosphate homeostasis, vitamin D influences muscle function, cardiovascular homeostasis, nervous function, and the immune response. Vitamin D deficiency/insufficiency has been associated with muscle weakness and a high incidence of various chronic diseases such as cardiovascular disease, cancer, multiple sclerosis, and type 1 and 2 diabetes. Most importantly, low vitamin D status has been found to be an independent predictor of all-cause mortality. Several recent randomized controlled trials support the assumption that vitamin D can improve muscle strength, glucose homeostasis, and cardiovascular risk markers. In addition, vitamin D may reduce cancer incidence and elevated blood pressure. Since the prevalence of vitamin D deficiency/insufficiency is high throughout the world, there is a need to improve vitamin D status in the general adult population. However, the currently recommended daily vitamin D intake of 5–15 \(\mu\)g is too low to achieve an adequate vitamin D status in individuals with only modest skin synthesis. Thus, there is a need to recommend a vitamin D intake that is effective for achieving adequate circulating 25-hydroxyvitamin D concentrations (>75 nmol/L).
Author: | Armin ZittermannORCiDGND, Jan GummertORCiDGND |
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URN: | urn:nbn:de:hbz:294-78226 |
DOI: | https://doi.org/10.3390/nu2040408 |
Parent Title (English): | Nutrients |
Publisher: | MDPI |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/02/03 |
Date of first Publication: | 2010/03/25 |
Publishing Institution: | Ruhr-Universität Bochum, Universitätsbibliothek |
Tag: | cancer; cardiovascular; diet; mortality; ultraviolet B radiation; vitamin D |
Volume: | 2 |
Issue: | 4 |
First Page: | 408 |
Last Page: | 425 |
Institutes/Facilities: | Herz- und Diabeteszentrum NRW, Klinik für Thorax- und Kardiovaskularchirurgie |
Dewey Decimal Classification: | Technik, Medizin, angewandte Wissenschaften / Medizin, Gesundheit |
open_access (DINI-Set): | open_access |
Licence (English): | Creative Commons - CC BY 3.0 Unported - Attribution 3.0 Unported |