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Laccase-Catalyzed Derivatization of Antibiotics with Sulfonamide or Sulfone Structures
- Trametes spec. laccase (EC 1.10.3.2.) mediates the oxidative coupling of antibiotics with sulfonamide or sulfone structures with 2,5-dihydroxybenzene derivatives to form new heterodimers and heterotrimers. These heteromolecular hybrid products are formed by nuclear amination of the p-hydroquinones with the primary amino group of the sulfonamide or sulfone antibiotics, and they inhibited in vitro the growth of Staphylococcus species, including multidrug-resistant strains.
Author: | Annett Mikolasch, Veronika Hahn |
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URN: | urn:nbn:de:gbv:9-opus-57218 |
DOI: | https://doi.org/10.3390/microorganisms9112199 |
ISSN: | 2076-2607 |
Parent Title (English): | Microorganisms |
Publisher: | MDPI |
Editor: | Annett Mikolasch, Mariam Gaid |
Document Type: | Article |
Language: | English |
Date of first Publication: | 2021/10/21 |
Release Date: | 2021/11/08 |
Tag: | antibacterial activity; antimicrobial resistance (AMR); biotransformation; laccase; methicillin-resistant; multidrug resistance (MDR); sulfonamide antibiotics; β-lactam antibiotics |
GND Keyword: | - |
Volume: | 9 |
Issue: | 11 |