Ulf Jensen-Kondering, Christoph J. Maurer, Hanna C. B. Brudermann, Marielle Ernst, Sam Sedaghat, Nils G. Margraf, Thomas Bahmer, Olav Jansen, Jawed Nawabi, Estelle Vogt, Laura Büttner, Eberhard Siebert, Michael Bartl, Volker Maus, Gregor Werding, Marc Schlamann, Nuran Abdullayev, Benjamin Bender, Vivien Richter, Annerose Mengel, Siri Göpel, Ansgar Berlis, Astrid Grams, Valentin Ladenhauf, Elke R. Gizewski, Philipp Kindl, Victor Schulze-Zachau, Marios Psychogios, Inke R. König, Stefan Sondermann, Sönke Wallis, Norbert Brüggemann, Peter Schramm, Alexander Neumann
- Background
Coronavirus disease 2019 (COVID-19) is an infection which can affect the central nervous system. In this study, we sought to investigate associations between neuroimaging findings with clinical, demographic, blood and cerebrospinal fluid (CSF) parameters, pre-existing conditions and the severity of acute COVID-19.
Materials and methods
Retrospective multicenter data retrieval from 10 university medical centers in Germany, Switzerland and Austria between February 2020 and September 2021. We included patients with COVID-19, acute neurological symptoms and cranial imaging. We collected demographics, neurological symptoms, COVID-19 severity, results of cranial imaging, blood and CSF parameters during the hospital stay.
Results
442 patients could be included. COVID-19 severity was mild in 124 (28.1%) patients (moderate n = 134/30.3%, severe n = 43/9.7%, critical n = 141/31.9%). 220 patients (49.8%) presented with respiratory symptoms, 167 (37.8%) presented withBackground
Coronavirus disease 2019 (COVID-19) is an infection which can affect the central nervous system. In this study, we sought to investigate associations between neuroimaging findings with clinical, demographic, blood and cerebrospinal fluid (CSF) parameters, pre-existing conditions and the severity of acute COVID-19.
Materials and methods
Retrospective multicenter data retrieval from 10 university medical centers in Germany, Switzerland and Austria between February 2020 and September 2021. We included patients with COVID-19, acute neurological symptoms and cranial imaging. We collected demographics, neurological symptoms, COVID-19 severity, results of cranial imaging, blood and CSF parameters during the hospital stay.
Results
442 patients could be included. COVID-19 severity was mild in 124 (28.1%) patients (moderate n = 134/30.3%, severe n = 43/9.7%, critical n = 141/31.9%). 220 patients (49.8%) presented with respiratory symptoms, 167 (37.8%) presented with neurological symptoms first. Acute ischemic stroke (AIS) was detected in 70 (15.8%), intracranial hemorrhage (IH) in 48 (10.9%) patients. Typical risk factors were associated with AIS; extracorporeal membrane oxygenation therapy and invasive ventilation with IH. No association was found between the severity of COVID-19 or blood/CSF parameters and the occurrence of AIS or IH.
Discussion
AIS was the most common finding on cranial imaging. IH was more prevalent than expected but a less common finding than AIS. Patients with IH had a distinct clinical profile compared to patients with AIS. There was no association between AIS or IH and the severity of COVID-19. A considerable proportion of patients presented with neurological symptoms first. Laboratory parameters have limited value as a screening tool.…
MetadatenAuthor: | Ulf Jensen-Kondering, Christoph J. Maurer, Hanna C. B. Brudermann, Marielle Ernst, Sam Sedaghat, Nils G. Margraf, Thomas Bahmer, Olav Jansen, Jawed Nawabi, Estelle Vogt, Laura Büttner, Eberhard Siebert, Michael Bartl, Volker Maus, Gregor Werding, Marc Schlamann, Nuran Abdullayev, Benjamin Bender, Vivien Richter, Annerose Mengel, Siri Göpel, Ansgar BerlisGND, Astrid Grams, Valentin Ladenhauf, Elke R. Gizewski, Philipp Kindl, Victor Schulze-Zachau, Marios Psychogios, Inke R. König, Stefan Sondermann, Sönke Wallis, Norbert Brüggemann, Peter Schramm, Alexander Neumann |
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URN: | urn:nbn:de:bvb:384-opus4-1035529 |
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Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/103552 |
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ISSN: | 0340-5354OPAC |
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ISSN: | 1432-1459OPAC |
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Parent Title (English): | Journal of Neurology |
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Publisher: | Springer Science and Business Media LLC |
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Place of publication: | Berlin |
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Type: | Article |
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Language: | English |
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Year of first Publication: | 2023 |
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Publishing Institution: | Universität Augsburg |
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Release Date: | 2023/04/14 |
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Tag: | Neurology (clinical); Neurology |
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Volume: | 270 |
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Issue: | 5 |
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First Page: | 2349 |
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Last Page: | 2359 |
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DOI: | https://doi.org/10.1007/s00415-023-11608-2 |
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Institutes: | Medizinische Fakultät |
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| Medizinische Fakultät / Universitätsklinikum |
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| Medizinische Fakultät / Lehrstuhl für Diagnostische und Interventionelle Neuroradiologie |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Licence (German): | CC-BY 4.0: Creative Commons: Namensnennung (mit Print on Demand) |
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