One-pot route to β-adrenergic blockers via enantioselective organocatalysed epoxidation of terminal alkenes as a key step
Files
Language
en
Document Type
Article
Issue Date
2016-10-04
Issue Year
2014
Authors
Held, Felix E.
Wei, Shengwei
Eder, Kathrin
Tsogoeva, Svetlana B.
Editor
Abstract
A convenient and environmentally attractive one-pot two-step process for the synthesis of β-adrenergic blockers via Shi's organocatalytic epoxidation of terminal alkenes and subsequent aminolysis reaction of epoxides with isopropylamine under mild reaction conditions has been developed.
Journal Title
RSC Advances
Volume
4
Issue
62
Citation
RSC Advances 4.62 (2014): S. 32796-32801. http://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra04011b#!divAbstract