DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder

Please always quote using this URN: urn:nbn:de:bvb:20-opus-135285
  • Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. We investigated the role of DCLK1 variants in three psychiatric disorders that have neuro-cognitive dysfunctions: schizophrenia (SCZ), bipolar affective disorder (BP) and attention deficit/hyperactivity disorder (ADHD). We mined six genome wide association studies (GWASs) that were available publically or throughDoublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. We investigated the role of DCLK1 variants in three psychiatric disorders that have neuro-cognitive dysfunctions: schizophrenia (SCZ), bipolar affective disorder (BP) and attention deficit/hyperactivity disorder (ADHD). We mined six genome wide association studies (GWASs) that were available publically or through collaboration; three for BP, two for SCZ and one for ADHD. We also genotyped the DCLK1 region in additional samples of cases with SCZ, BP or ADHD and controls that had not been whole-genome typed. In total, 9895 subjects were analysed, including 5308 normal controls and 4,587 patients (1,125 with SCZ, 2,496 with BP and 966 with ADHD). Several DCLK1 variants were associated with disease phenotypes in the different samples. The main effect was observed for rs7989807 in intron 3, which was strongly associated with SCZ alone and even more so when cases with SCZ and ADHD were combined (P-value = 4x10\(^{-5}\) and 4x10\(^{-6}\), respectively). Associations were also observed with additional markers in intron 3 (combination of SCZ, ADHD and BP), intron 19 (SCZ+BP) and the 3'UTR (SCZ+BP). Our results suggest that genetic variants in DCLK1 are associated with SCZ and, to a lesser extent, with ADHD and BP. Interestingly the association is strongest when SCZ and ADHD are considered together, suggesting common genetic susceptibility. Given that DCLK1 variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity.show moreshow less

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Author: Bjarte Havik, Franziska A. Degenhardt, Stefan Johansson, Carla P. D. Fernandes, Anke Hinney, André Scherag, Helle Lybaek, Srdjan Djurovic, Andrea Christoforou, Kari M. Ersland, Sudheer Giddaluru, Michael C. O'Donovan, Michael J. Owen, Nick Craddock, Thomas W. Mühleisen, Manuel Mattheisen, Benno G. Schimmelmann, Tobias Renner, Andreas Warnke, Beate Herpertz-Dahlmann, Judith Sinzig, Özgür Albayrak, Marcella Rietschel, Markus M. Nöthen, Clive R. Bramham, Thomas Werge, Johannes Hebebrand, Jan Haavik, Ole A. Andreassen, Sven Cichon, Vidar M. Steen, Stephanie Le Hellard
URN:urn:nbn:de:bvb:20-opus-135285
Document Type:Journal article
Faculties:Medizinische Fakultät / Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie
Language:English
Parent Title (English):PLoS One
Year of Completion:2012
Volume:7
Issue:4
Pagenumber:e35424
Source:PLoS ONE 7(4): e35424. doi:10.1371/journal.pone.0035424
DOI:https://doi.org/10.1371/journal.pone.0035424
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 618 Gynäkologie, Geburtsmedizin, Pädiatrie, Geriatrie
Tag:BDNF; VAL66MET polymorphism; bipolar disorder; deficit hyperactivity disorder; doublecortine-like; endophenotype; genes; genome-wide association; kinase; psychosis
Release Date:2018/03/23
EU-Project number / Contract (GA) number:245009
OpenAIRE:OpenAIRE
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung