- AutorIn
- Haifeng Xu Institute for Integrative Nanosciences, Leibniz IFW Dresden
- Mariana Medina-SánchezInstitute for Integrative Nanosciences, Leibniz IFW Dresden
- Oliver G. SchmidtInstitute for Integrative Nanosciences, Leibniz IFW Dresden#Technische Universität Chemnitz
- Titel
- Magnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:ch1-qucosa2-799604
- Quellenangabe
- Angewandte Chemie Jahrgang: 132
Heft: 35
Seiten: 15029-15037
ISSN: 0044–8249
E-ISSN: 1521–3757 - Erstveröffentlichung
- 2020
- Abstract (EN)
- An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captured within the HA microflake, the assembly is trapped and transported by a magnetically-driven helical microcarrier. The trapping of the sperm-microflake occurs by a local vortex induced by the microcarrier during rotation-translation under a rotating magnetic field. After transport, the microflake is enzymatically hydrolyzed by local proteases, allowing sperm to escape and finally reach the target location. This cargo-delivery system represents a new concept to transport not only multiple motile sperm but also other actively moving biological cargoes.
- Andere Ausgabe
- Angewandte Chemie
DOI: 10.1002/ange.202005657 - Freie Schlagwörter (EN)
- enzymatic release, mature sperm selection, microflake synthesis, micromotor, sperm swarm transport
- Klassifikation (DDC)
- 621.3
- Verlag
- Wiley, Weinheim
- Publizierende Institution
- Technische Universität Chemnitz, Chemnitz
- Förder- / Projektangaben
- European Research Council (ERC)
Horizon 2020 ID: 835268, 853609 - Deutsche Forschungsgemeinschaft (DFG)
ID: SPP 1726 - Leibniz Program of the German Research Foundation ID: SCHM 1298/26-1
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:ch1-qucosa2-799604
- Veröffentlichungsdatum Qucosa
- 22.07.2022
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY-NC 4.0