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Primary Liver Cancers : Connecting the Dots of Cellular Studies and Epidemiology with Metabolomics

  • Liver cancers are rising worldwide. Between molecular and epidemiological studies, a research gap has emerged which might be amenable to the technique of metabolomics. This review investigates the current understanding of liver cancer’s trends, etiology and its correlates with existing literature for hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and hepatoblastoma (HB). Among additional factors, the literature reports dysfunction in the tricarboxylic acid metabolism, primarily for HB and HCC, and point mutations and signaling for CCA. All cases require further investigation of upstream and downstream events. All liver cancers reported dysfunction in the WNT/β-catenin and P13K/AKT/mTOR pathways as well as changes in FGFR. Metabolites of IHD1, IDH2, miRNA, purine, Q10, lipids, phosphatidylcholine, phosphatidylethanolamine, acylcarnitine, 2-HG and propionyl-CoA emerged as crucial and there was an attempt to elucidate the WNT/β-catenin and P13K/AKT/mTOR pathways metabolomically.

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Metadaten
Author:Shoma Barbara BerkemeyerORCiD
Title (English):Primary Liver Cancers : Connecting the Dots of Cellular Studies and Epidemiology with Metabolomics
URN:urn:nbn:de:bsz:959-opus-38377
URL:https://www.mdpi.com/1422-0067/24/3/2409
DOI:https://doi.org/10.3390/ijms24032409
ISSN:1422-0067
Parent Title (English):International Journal of Molecular Sciences (IJMS)
Document Type:Article
Language:English
Year of Completion:2023
Release Date:2023/02/06
Tag:P13K/AKT/mTOR pathway; TCA; WNT/β-catenin pathway; cholangiocarcinoma; hepatoblastoma; hepatocellular carcinoma; lipid; metabolomics
Volume:24
Issue:3
Article Number:2409
Page Number:20
Faculties:Fakultät AuL
DDC classes:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin, Gesundheit
Review Status:Veröffentlichte Fassung/Verlagsversion
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International