- AutorIn
- Chris Händel
- B.U. Sebastian Schmidt
- Jürgen Schiller
- Undine Dietrich
- Till Möhn
- Tobias R. Kießling
- Steve Pawlizak
- Anatol W. Fritsch
- Lars-Christian Horn
- Susanne Briest
- Michael Höckel
- Mareike Zink
- Josef A. Käs
- Titel
- Cell membrane softening in human breast and cervical cancer cells
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-803881
- Quellenangabe
- New Journal of Physics : The open access journal at the forefront of physics
Erscheinungsjahr: 2015
Jahrgang: 17
Artikelnummer: 083008 - Erstveröffentlichung
- 2015
- Abstract (EN)
- Biomechanical properties are key to many cellular functions such as cell division and cell motility and thus are crucial in the development and understanding of several diseases, for instance cancer. The mechanics of the cellular cytoskeleton have been extensively characterized in cells and artificial systems. The rigidity of the plasma membrane, with the exception of red blood cells, is unknown and membrane rigidity measurements only exist for vesicles composed of a few synthetic lipids. In this study, thermal fluctuations of giant plasma membrane vesicles (GPMVs) directly derived from the plasma membranes of primary breast and cervical cells, as well as breast cell lines, are analyzed. Cell blebs or GPMVs were studied via thermal membrane fluctuations and mass spectrometry. It will be shown that cancer cell membranes are significantly softer than their non-malignant counterparts. This can be attributed to a loss of fluid raft forming lipids in malignant cells. These results indicate that the reduction of membrane rigidity promotes aggressive blebbing motion in invasive cancer cells.
- Andere Ausgabe
- Link zur Erstveröffentlichung
Link: https://dx.doi.org/10.1088/1367-2630/17/8/083008 - Freie Schlagwörter (EN)
- cancer, biomembranes, membrane rigidity
- Klassifikation (DDC)
- 530
- Verlag
- IOP Publishing, Bristol
- Förder- / Projektangaben
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-803881
- Veröffentlichungsdatum Qucosa
- 12.08.2022
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY 4.0