- AutorIn
- Dennis Löffler
- Katja Brocke-Heidrich
- Gabriele Pfeifer
- Claudia Stocsits
- Jörg Hackermüller
- Antje K. Kretzschmar
- Renate Burger
- Martin Gramatzki
- Conny Blumert
- Kay Bauer
- Helena Cvijic
- Kerstin Ullmann
- Peter F. Stadler
- Friedemann Horn
- Titel
- Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of micro-RNA-21 through a highly conserved enhancer
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-321287
- Quellenangabe
- Blood Erscheinungsort: Washington
Verlag: American Society of Hematology
Erscheinungsjahr: 2007
Jahrgang: 110
Heft: 4
Seiten: 1330-1333
ISSN: 0006-4971
E-ISSN: 1528-0020 - Erstveröffentlichung
- 2007
- Abstract (EN)
- Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6–dependent survival and growth of multiple myeloma cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is controlled by an upstream enhancer containing 2 Stat3 binding sites strictly conserved since the first observed evolutionary appearance of miR-21 and Stat3. MiR-21 induction by IL-6 was strictly Stat3 dependent. Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3.
- Freie Schlagwörter (EN)
- Biochemistry, Evolutionary biology, RNA
- Klassifikation (DDC)
- 572.8
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:15-qucosa2-321287
- Veröffentlichungsdatum Qucosa
- 08.11.2018
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch