- AutorIn
- Karin R. Pillunat Technical University Dresden, Medical Faculty Carl Gustav Carus, Department of Ophthalmology
- Greta A. KocketTechnical University Dresden, Medical Faculty Carl Gustav Carus, Department of Ophthalmology
- Robert HerberTechnical University Dresden, Medical Faculty Carl Gustav Carus, Department of Ophthalmology
- Carolin S. Jasper
- Janine Lenk
- Lutz E. Pillunat
- Titel
- Efficacy of selective laser trabeculoplasty on lowering intraocular pressure fluctuations and nocturnal peak intraocular pressure in treated primary open-angle glaucoma patients
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-895730
- Quellenangabe
- Graefe's archive for clinical and experimental ophthalmology : official organ of the Club Jules Gonin
Erscheinungsjahr: 2023
Jahrgang: 261
Seiten: 1979-1985
E-ISSN: 1435-702X - Erstveröffentlichung
- 2022
- Abstract (EN)
- Purpose To investigate the efficacy of adjunctive selective laser trabeculoplasty (SLT) in reducing 24-h intraocular pressure (IOP) fluctuations and nocturnal IOP peaks. Methods In this prospective interventional case series, 157 medically treated eyes of 157 patients with primary open-angle glaucoma (POAG) who were assigned SLT to further reduce IOP were consecutively included. Each patient had a complete glaucoma work-up and 24-h IOP monitoring (6 measurements, including one in the supine position) taken before and on average 6 months after SLT. The main outcome measures were the reduction of 24-h IOP fluctuations and nocturnal peak IOP. Secondary outcome measures were success rates, factors influencing the reduction of high 24-h IOP fluctuations and nocturnal peak IOP, complications, and severe adverse events. Results Medicated mean 24-h IOP (mmHg) was statistically significantly reduced from 15.1 ± 2.6 to 13.8 ± 2.4 (P < 0.001) and IOP fluctuations from 6.5 ± 2.7 to 5.4 ± 2.6 (P < 0.001) 6 months after SLT. Ninety-four eyes (59.9%) initially had high IOP fluctuations (more than 5 mmHg). These were reduced from 8.1 ± 2.3 to 5.6 ± 2.7 at 6 months (P < 0.001). Fifty-two eyes (55.3%) had fluctuations below 5 mmHg post-SLT which was defined as success. Fifty-one patients (32.5%) had nocturnal IOP peaks. In these cases, nocturnal IOP was reduced by 19.2% from 20.1 ± 3.4 to 16.2 ± 3.3 mmHg at 6 months (P = 0.001). Conclusions The current study demonstrates that adjunctive SLT not only reduces mean 24-h IOP in treated POAG patients, but also has an additional benefit in reducing IOP fluctuations and nocturnal peak IOP.
- Andere Ausgabe
- Link zum Artikel der zuerst in der Zeitschrift 'Graefe's archive for clinical and experimental ophthalmology' bei Springer Link erschienen ist.
DOI: 10.1007/s00417-022-05897-y - Freie Schlagwörter (DE)
- Selektive Lasertrabekuloplastik, zirkadiane Spannungskurven, 24-stündige IOD-Fluktuation, nächtlicher Spitzen-IOD
- Freie Schlagwörter (EN)
- Selective laser trabeculoplasty, Circadian tension curves, 24-h IOP fluctuation, Nocturnal peak IOP
- Klassifikation (DDC)
- 610
- Verlag
- Springer, Berlin ; Heidelberg
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-895730
- Veröffentlichungsdatum Qucosa
- 19.03.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY 4.0