- AutorIn
- Martin Eichler Technische Universität Dresden, Universitätsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik I
- Susanne SingerUniversity Hospital Mainz, Institute for Medical Biostatistics, Epidemiology and Informatic
- Leopold HentschelTechnische Universität Dresden, Medizinische Fakultät, Nationales Zentrum für Tumorerkrankungen (NCT/UCC)
- Stephan Richter
- Peter Hohenberger
- Bernd Kasper
- Dimosthenis Andreou
- Daniel Pink
- Jens Jakob
- Robert Grützmann
- Stephen Fung
- Eva Wardelmann
- Karin Arndt
- Vitali Heidt
- Sergio Armando Zapata Bonilla
- Verena I. Gaidzik
- Helena K. Jambor
- Jürgen Weitz
- Klaus-Dieter Schaser
- Martin Bornhäuser
- Titel
- The association of Health-Related Quality of Life and 1-year-survival in sarcoma patients
- Untertitel
- results of a Nationwide Observational Study (PROSa)
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa2-890492
- Quellenangabe
- British Journal of Cancer
Erscheinungsjahr: 2022
Jahrgang: 126
Seiten: 1346-1354
E-ISSN: 1532-1827 - Erstveröffentlichung
- 2022
- Abstract (EN)
- BACKGROUND: Sarcomas are rare cancers of high heterogeneity. Health-Related Quality of Life (HRQoL) has been shown to be a prognostic factor for survival in other cancer entities but it is unclear whether this applies to sarcoma patients. PATIENTS AND METHODS: HRQoL was prospectively assessed in adult sarcoma patients from 2017 to 2020 in 39 German recruiting sites using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQC30). Vital status was ascertained over the course of 1 year. HRQoL domains were analysed by multivariable cox-regressions including clinical and socio-economic risk factors. RESULTS: Of 1102 patients, 126 (11.4%) died during follow-up. The hazard ratio (HR) for global health was 0.73 per 10-point increase (95% confidence interval (CI) 0.64–0.85). HR for the HRQoL-summary score was 0.74 (CI 0.64–0.85) and for physical functioning 0.82 (CI 0.74–0.89). There was also evidence that fatigue (HR 1.17, CI 1.10–1.25), appetite loss (HR 1.15, CI 1.09–1.21) and pain (HR 1.14, CI 1.08–1.20) are prognostic factors for survival. CONCLUSION: Our study adds sarcoma-specific evidence to the existing data about cancer survival in general. Clinicians and caregivers should be aware of the relations between HRQoL and survival probability and include HRQoL in routine assessment.
- Andere Ausgabe
- Link zum Artikel, der zuerst in der Zeitschrift „British Journal of Cancer” erschienen ist.
DOI: 10.1038/s41416-022-01702-z - Freie Schlagwörter (DE)
- Sarkome, Krebs, gesundheitsbezogene Lebensqualität
- Freie Schlagwörter (EN)
- Sarcomas, cancer, Health-Related Quality of Life
- Klassifikation (DDC)
- 610
- Förder- / Projektangaben
- Deutsche Krebshilfe ID: 111713
- Version / Begutachtungsstatus
- publizierte Version / Verlagsversion
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa2-890492
- Veröffentlichungsdatum Qucosa
- 02.02.2024
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY 4.0