- AutorIn
- Dipl.-Ing. Martin Schmidt
- Prof. Mathias Baumert
- Prof. Dr.-Ing. habil. Hagen Malberg
- Dr.-Ing. Sebastian Zaunseder
- Titel
- T Wave Amplitude Correction of QT Interval Variability for Improved Repolarization Lability Measurement
- Zitierfähige Url:
- https://nbn-resolving.org/urn:nbn:de:bsz:14-qucosa-217300
- Quellenangabe
- Frontiers in Physiology (April 2016), 7, ISSN: 1664-042X. DOI: 10.3389/fphys.2016.00216. Artikelnr.: 216
- Abstract (EN)
- Objectives: The inverse relationship between QT interval variability (QTV) and T wave amplitude potentially confounds QT variability assessment. We quantified the influence of the T wave amplitude on QTV in a comprehensive dataset and devised a correction formula. Methods: Three ECG datasets of healthy subjects were analyzed to model the relationship between T wave amplitude and QTV. To derive a generally valid correction formula, linear regression analysis was used. The proposed correction formula was applied to patients enrolled in the Evaluation of Defibrillator in Non-Ischemic Cardiomyopathy Treatment Evaluation trial (DEFINITE) to assess the prognostic significance of QTV for all-cause mortality in patients with non-ischemic dilated cardiomyopathy. Results: A strong inverse relationship between T wave amplitude and QTV was demonstrated, both in healthy subjects (R2 = 0.68, p < 0.001) and DEFINITE patients (R2 = 0.20, p < 0.001). Applying the T wave amplitude correction to QTV achieved 2.5-times better group discrimination between patients enrolled in the DEFINITE study and healthy subjects. Kaplan-Meier estimator analysis showed that T wave amplitude corrected QTVi is inversely related to survival (p < 0.01) and a significant predictor of all-cause mortality. Conclusion: We have proposed a simple correction formula for improved QTV assessment. Using this correction, predictive value of QTV for all-cause mortality in patients with non-ischemic cardiomyopathy has been demonstrated.
- Andere Ausgabe
- DOI: 10.3389/fphys.2016.00216
- Link zum Artikel, der zuerst in der Zeitschrift 'Frontiers in Physiologie' erschienen ist.
Link: http://dx.doi.org/10.3389/fphys.2016.00216 - Freie Schlagwörter (DE)
- EKG, QT-Intervallvariabilität, T-Wellenamplitude, Risikostratifizierung, DEFINITE, TU Dresden, Publikationsfond
- Freie Schlagwörter (EN)
- ECG, QT interval variability, T wave amplitude, risk stratification, DEFINITE, TU Dresden, Publishing Fund
- Klassifikation (DDC)
- 610
- Klassifikation (RVK)
- XA 10000
- Verlag
- Frontiers Research Foundation, Lausanne
- URN Qucosa
- urn:nbn:de:bsz:14-qucosa-217300
- Veröffentlichungsdatum Qucosa
- 19.01.2017
- Dokumenttyp
- Artikel
- Sprache des Dokumentes
- Englisch
- Lizenz / Rechtehinweis
- CC BY 4.0