Computer-aided design of novel siderophores: Pyridinochelin

Please always quote using this URN: urn:nbn:de:0297-zib-5887

Pyridinochelin, a novel catecholate type siderophore, has been designed on the basis of the active analog enterobactin. Growth promotion tests indicate that this synthetic siderophore feeds various pathogenic bacteria effectively with iron even though it lacks one catecholate group compared to enterobactin. The superposition of the siderophore structures suggests that the structure of the skeleton connecting the catecholate groups might be an important factor for the iron transport.

Metadaten
Author:	Michael Meyer, Rüdiger Schnurre, Rolf Reissbrodt, Wolfram Trowitzsch-Kienast
Document Type:	ZIB-Report
Tag:	bioorganic chemistry; drug design; iron transport; molecular modeling; siderophore
MSC-Classification:	92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C40 Biochemistry, molecular biology
	92-XX BIOLOGY AND OTHER NATURAL SCIENCES / 92Cxx Physiological, cellular and medical topics / 92C50 Medical applications (general)
CCS-Classification:	J. Computer Applications / J.2 PHYSICAL SCIENCES AND ENGINEERING
	J. Computer Applications / J.3 LIFE AND MEDICAL SCIENCES
PACS-Classification:	80.00.00 INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY / 87.00.00 Biological and medical physics / 87.15.-v Biomolecules: structure and physical properties
	80.00.00 INTERDISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY / 87.00.00 Biological and medical physics / 87.16.-b Subcellular structure and processes / 87.16.Uv Active transport processes
Date of first Publication:	2000/06/15
Series (Serial Number):	ZIB-Report (00-20)
ZIB-Reportnumber:	00-20
Published in:	A rev. vers. appeared in: Z. Naturforsch 56c (2001) pp. 540-546

Open Access