Fast oscillatory activity in the anterior cingulate cortex: dopaminergic modulation and effect of perineuronal net loss.

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Version: Final published version
Serval ID
serval:BIB_D0BDBA25EF66
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Fast oscillatory activity in the anterior cingulate cortex: dopaminergic modulation and effect of perineuronal net loss.
Journal
Frontiers in Cellular Neuroscience
Author(s)
Steullet P., Cabungcal J.H., Cuénod M., Do K.Q.
ISSN
1662-5102 (Electronic)
ISSN-L
1662-5102
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
8
Pages
244
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Dopamine release in the prefrontal cortex plays a critical role in cognitive function such as working memory, attention and planning. Dopamine exerts complex modulation on excitability of pyramidal neurons and interneurons, and regulates excitatory and inhibitory synaptic transmission. Because of the complexity of this modulation, it is difficult to fully comprehend the effect of dopamine on neuronal network activity. In this study, we investigated the effect of dopamine on local high-frequency oscillatory neuronal activity (in β band) in slices of the mouse anterior cingulate cortex (ACC). We found that dopamine enhanced the power of these oscillations induced by kainate and carbachol, but did not affect their peak frequency. Activation of D2R and in a lesser degree D1R increased the oscillation power, while activation of D4R had no effect. These high-frequency oscillations in the ACC relied on both phasic inhibitory and excitatory transmission and functional gap junctions. Thus, dopamine released in the ACC promotes high-frequency synchronized local cortical activity which is known to favor information transfer, fast selection and binding of distributed neuronal responses. Finally, the power of these oscillations was significantly enhanced after degradation of the perineuronal nets (PNNs) enwrapping most parvalbumin interneurons. This study provides new insights for a better understanding of the abnormal prefrontal gamma activity in schizophrenia (SZ) patients who display prefrontal anomalies of both the dopaminergic system and the PNNs.
Keywords
anterior cingulate cortex, dopamine receptors, beta oscillations, perineuronal nets, parvalbumin interneurons, mouse
Pubmed
Web of science
Open Access
Yes
Create date
15/12/2015 9:56
Last modification date
20/08/2019 15:51
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