Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_A50FDF38AD9B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019.
Journal
The lancet. Diabetes & endocrinology
Working group(s)
GBD 2019 Diabetes Mortality Collaborators
Contributor(s)
Duncan B.B., Stein C., Ong K.L., Vos T., Abbafati C., Abbasi-Kangevari M., Abdelmasseh M., Abdoli A., Abd-Rabu R., Abolhassani H., Abu-Gharbieh E., Accrombessi MMK, Adnani QES, Afzal M.S., Agarwal G., Agrawaal K.K., Agudelo-Botero M., Ahinkorah B.O., Ahmad S., Ahmad T., Ahmadi K., Ahmadi S., Ahmadi A., Ahmed A., Ahmed Salih Y., Akande-Sholabi W., Akram T., Al Hamad H., Al-Aly Z., Alcalde-Rabanal J.E., Alipour V., Aljunid S.M., Al-Raddadi R.M., Alvis-Guzman N., Amini S., Ancuceanu R., Andrei T., Andrei C.L., Anjana R.M., Ansar A., Antonazzo I.C., Antony B., Anyasodor A.E., Arabloo J., Arizmendi D., Armocida B., Artamonov A.A., Arulappan J., Aryan Z., Asgari S., Ashraf T., Astell-Burt T., Atorkey P., Atout MMW, Ayanore M.A., Badiye A.D., Baig A.A., Bairwa M., Baker J.L., Baltatu O.C., Banik P.C., Barnett A., Barone MTU, Barone-Adesi F., Barrow A., Bedi N., Belete R., Belgaumi U.I., Bell A.W., Bennett D.A., Bensenor I.M., Beran D., Bhagavathula A.S., Bhaskar S., Bhattacharyya K., Bhojaraja V.S., Bijani A., Bikbov B., Birara S., Bodolica V., Bonny A., Brenner H., Briko N.I., Butt Z.A., Caetano Dos Santos F.L., Cámera L.A., Campos-Nonato I.R., Cao Y., Cao C., Cerin E., Chakraborty P.A., Chandan J.S., Chattu V.K., Chen S., Choi J.J., Choudhari S.G., Chowdhury E.K., Chu D.T., Corso B., Dadras O., Dai X., Damasceno AAM, Dandona L., Dandona R., Dávila-Cervantes C.A., De Neve J.W., Denova-Gutiérrez E., Dhamnetiya D., Diaz D., Ebtehaj S., Edinur H.A., Eftekharzadeh S., El Sayed I., Elgendy I.Y., Elhadi M., Elmonem M.A., Faisaluddin M., Farooque U., Feng X., Fernandes E., Fischer F., Flood D., Freitas M., Gaal P.A., Gad M.M., Gaewkhiew P., Getacher L., Ghafourifard M., Ghanei Gheshlagh R., Ghashghaee A., Ghith N., Ghozali G., Gill P.S., Ginawi I.A., Glushkova E.V., Golechha M., Gopalani S.V., Guimarães R.A., Gupta R.D., Gupta R., Gupta V.K., Gupta V.B., Gupta S., Habtewold T.D., Hafezi-Nejad N., Halwani R., Hanif A., Hankey G.J., Haque S., Hasaballah A.I., Hasan S.S., Hashi A., Hassanipour S., Hay S.I., Hayat K., Heidari M., Hossain MBH, Hossain S., Hosseini M., Hoveidamanesh S., Huang J., Humayun A., Hussain R., Hwang B.F., Ibitoye S.E., Ikuta K.S., Inbaraj L.R., Iqbal U., Islam M.S., Islam SMS, Islam R.M., Ismail N.E., Isola G., Itumalla R., Iwagami M., Iyamu I.O., Jahani M.A., Jakovljevic M., Jayawardena R., Jha R.P., John O., Jonas J.B., Joo T., Kabir A., Kalhor R., Kamath A., Kanchan T., Kandel H., Kapoor N., Kayode G.A., Kebede S.A., Keshavarz P., Keykhaei M., Khader Y.S., Khajuria H., Khan M.A., Khan M.N., Khan M., Khater A.M., Khoja TAM, Khubchandani J., Kim M.S., Kim Y.J., Kimokoti R.W., Kisa S., Kisa A., Kivimäki M., Korshunov V.A., Korzh O., Koyanagi A., Krishan K., Kuate Defo B., Kumar G.A., Kumar N., Kusuma D., La Vecchia C., Lacey B., Larsson A.O., Lasrado S., Lee W.C., Lee C.B., Lee P.H., Lee SWH, Li M.C., Lim S.S., Lim L.L., Lucchetti G., Majeed A., Malik A.A., Mansouri B., Mantovani L.G., Martini S., Mathur P., McAlinden C., Mehedi N., Mekonnen T., Menezes R.G., Mersha A.G., Miao Jonasson J., Miazgowski T., Michalek I.M., Mirica A., Mirrakhimov E.M., Mirza A.Z., Mithra P., Mohammadian-Hafshejani A., Mohammadpourhodki R., Mohammed A., Mokdad A.H., Molokhia M., Monasta L., Moni M.A., Moradpour F., Moradzadeh R., Mostafavi E., Mueller U.O., Murray CJL, Mustafa A., Nagel G., Nangia V., Naqvi A.A., Nayak B.P., Nazari J., Ndejjo R., Negoi R.I., Neupane Kandel S., Nguyen C.T., Nguyen HLT, Noubiap J.J., Nowak C., Oancea B., Odukoya O.O., Oguntade A.S., Ojo T.T., Olagunju A.T., Onwujekwe O.E., Ortiz A., Owolabi M.O., Palladino R., Panda-Jonas S., Pandi-Perumal S.R., Pardhan S., Parekh T., Parvizi M., Pepito VCF, Perianayagam A., Petcu I.R., Pilania M., Podder V., Polibin R.V., Postma M.J., Prashant A., Rabiee N., Rabiee M., Rahimi-Movaghar V., Rahman M.A., Rahman M.M., Rahman M., Rahmawaty S., Rajai N., Ram P., Rana J., Ranabhat K., Ranasinghe P., Rao C.R., Rao S., Rawaf S., Rawaf D.L., Rawal L., Renzaho AMN, Rezaei N., Rezapour A., Riahi S.M., Ribeiro D., Rodriguez JAB, Roever L., Rohloff P., Rwegerera G.M., Ryan P.M., Saber-Ayad M.M., Sabour S., Saddik B., Saeedi Moghaddam S., Sahebkar A., Sahoo H., Saif-Ur-Rahman K.M., Salimzadeh H., Samaei M., Sanabria J., Santric-Milicevic M.M., Sathian B., Sathish T., Schlaich M.P., Seidu A.A., Šekerija M., Senthil Kumar N., Seylani A., Shaikh M.A., Shamshad H., Shawon MSR, Sheikhbahaei S., Shetty J.K., Shiri R., Shivakumar K.M., Shuval K., Singh J.A., Singh A., Skryabin V.Y., Skryabina A.A., Sofi-Mahmudi A., Soheili A., Sun J., Szerencsés V., Szócska M., Tabarés-Seisdedos R., Tadbiri H., Tadesse E.G., Tariqujjaman M., Thankappan K.R., Thapar R., Thomas N., Timalsina B., Tobe-Gai R., Tonelli M., Tovani-Palone M.R., Tran B.X., Tripathy J.P., Tudor Car L., Tusa B.S., Uddin R., Upadhyay E., Valadan Tahbaz S., Valdez P.R., Vasankari T.J., Verma M., Villalobos-Daniel V.E., Vladimirov S.K., Vo B., Vu G.T., Vukovic R., Waheed Y., Wamai R.G., Werdecker A., Wickramasinghe N.D., Winkler A.S., Wubishet B.L., Xu X., Xu S., Yahyazadeh Jabbari S.H., Yatsuya H., Yaya S., Yazie TSY, Yi S., Yonemoto N., Yunusa I., Zadey S., Zaman S.B., Zamanian M., Zamora N., Zastrozhin M.S., Zastrozhina A., Zhang Z.J., Zhong C., Zmaili M., Zumla A., Naghavi M., Schmidt M.I.
ISSN
2213-8595 (Electronic)
ISSN-L
2213-8587
Publication state
Published
Issued date
03/2022
Peer-reviewed
Oui
Volume
10
Number
3
Pages
177-192
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.
We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990-2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals.
In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r <sup>2</sup> =0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (-28·4 to -2·9) for all diabetes, and by 21·0% (-33·0 to -5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (-13·6% [-28·4 to 3·4]) and for type 1 diabetes (-13·6% [-29·3 to 8·9]).
Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations.
Bill & Melinda Gates Foundation.
We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990-2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals.
In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r <sup>2</sup> =0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (-28·4 to -2·9) for all diabetes, and by 21·0% (-33·0 to -5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (-13·6% [-28·4 to 3·4]) and for type 1 diabetes (-13·6% [-29·3 to 8·9]).
Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations.
Bill & Melinda Gates Foundation.
Keywords
Adult, Diabetes Mellitus, Type 1/epidemiology, Diabetes Mellitus, Type 2, Global Burden of Disease, Global Health, Humans, Risk Factors
Pubmed
Web of science
Open Access
Yes
Create date
20/05/2022 18:16
Last modification date
25/01/2024 8:41
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