Discovery and refinement of loci associated with lipid levels.

Willer, C.J.; Willer, C.J.; Schmidt, E.M.; Sengupta, S.; Peloso, G.M.; Gustafsson, S.; Kanoni, S.; Ganna, A.; Chen, J.; Buchkovich, M.L.; Mora, S.; Beckmann, J.S.; Bragg-Gresham, J.L.; Chang, H.Y.; Demirkan, A.; Den Hertog, H.M.; Do, R.; Donnelly, L.A.; Ehret, G.B.; Esko, T.; Feitosa, M.F.; Ferreira, T.; Fischer, K.; Fontanillas, P.; Fraser, R.M.; Freitag, D.F.; Gurdasani, D.; Heikkilä, K.; Hyppönen, E.; Isaacs, A.; Jackson, A.U.; Johansson, A.; Johnson, T.; Kaakinen, M.; Kettunen, J.; Kleber, M.E.; Li, X.; Luan, J.; Lyytikäinen, L.P.; Magnusson, P.K.; Mangino, M.; Mihailov, E.; Montasser, M.E.; Müller-Nurasyid, M.; Nolte, I.M.; O'Connell, J.R.; Palmer, C.D.; Perola, M.; Petersen, A.K.; Sanna, S.; Saxena, R.; Service, S.K.; Shah, S.; Shungin, D.; Sidore, C.; Song, C.; Strawbridge, R.J.; Surakka, I.; Tanaka, T.; Teslovich, T.M.; Thorleifsson, G.; Van den Herik, E.G.; Voight, B.F.; Volcik, K.A.; Waite, L.L.; Wong, A.; Wu, Y.; Zhang, W.; Absher, D.; Asiki, G.; Barroso, I.; Been, L.F.; Bolton, J.L.; Bonnycastle, L.L.; Brambilla, P.; Burnett, M.S.; Cesana, G.; Dimitriou, M.; Doney, A.S.; Döring, A.; Elliott, P.; Epstein, S.E.; Eyjolfsson, G.I.; Gigante, B.; Goodarzi, M.O.; Grallert, H.; Gravito, M.L.; Groves, C.J.; Hallmans, G.; Hartikainen, A.L.; Hayward, C.; Hernandez, D.; Hicks, A.A.; Holm, H.; Hung, Y.J.; Illig, T.; Jones, M.R.; Kaleebu, P.; Kastelein, J.J.; Khaw, K.T.; Kim, E.; Klopp, N.; Komulainen, P.; Kumari, M.; Langenberg, C.; Lehtimäki, T.; Lin, S.Y.; Lindström, J.; Loos, R.J.; Mach, F.; McArdle, W.L.; Meisinger, C.; Mitchell, B.D.; Müller, G.; Nagaraja, R.; Narisu, N.; Nieminen, T.V.; Nsubuga, R.N.; Olafsson, I.; Ong, K.K.; Palotie, A.; Papamarkou, T.; Pomilla, C.; Pouta, A.; Rader, D.J.; Reilly, M.P.; Ridker, P.M.; Rivadeneira, F.; Rudan, I.; Ruokonen, A.; Samani, N.; Scharnagl, H.; Seeley, J.; Silander, K.; Stancáková, A.; Stirrups, K.; Swift, A.J.; Tiret, L.; Uitterlinden, A.G.; van Pelt, L.J.; Vedantam, S.; Wainwright, N.; Wijmenga, C.; Wild, S.H.; Willemsen, G.; Wilsgaard, T.; Wilson, J.F.; Young, E.H.; Zhao, J.H.; Adair, L.S.; Arveiler, D.; Assimes, T.L.; Bandinelli, S.; Bennett, F.; Bochud, M.; Boehm, B.O.; Boomsma, D.I.; Borecki, I.B.; Bornstein, S.R.; Bovet, P.; Burnier, M.; Campbell, H.; Chakravarti, A.; Chambers, J.C.; Chen, Y.D.; Collins, F.S.; Cooper, R.S.; Danesh, J.; Dedoussis, G.; de Faire, U.; Feranil, A.B.; Ferrières, J.; Ferrucci, L.; Freimer, N.B.; Gieger, C.; Groop, L.C.; Gudnason, V.; Gyllensten, U.; Hamsten, A.; Harris, T.B.; Hingorani, A.; Hirschhorn, J.N.; Hofman, A.; Hovingh, G.K.; Hsiung, C.A.; Humphries, S.E.; Hunt, S.C.; Hveem, K.; Iribarren, C.; Järvelin, M.R.; Jula, A.; Kähönen, M.; Kaprio, J.; Kesäniemi, A.; Kivimaki, M.; Kooner, J.S.; Koudstaal, P.J.; Krauss, R.M.; Kuh, D.; Kuusisto, J.; Kyvik, K.O.; Laakso, M.; Lakka, T.A.; Lind, L.; Lindgren, C.M.; Martin, N.G.; März, W.; McCarthy, M.I.; McKenzie, C.A.; Meneton, P.; Metspalu, A.; Moilanen, L.; Morris, A.D.; Munroe, P.B.; Njølstad, I.; Pedersen, N.L.; Power, C.; Pramstaller, P.P.; Price, J.F.; Psaty, B.M.; Quertermous, T.; Rauramaa, R.; Saleheen, D.; Salomaa, V.; Sanghera, D.K.; Saramies, J.; Schwarz, P.E.; Sheu, W.H.; Shuldiner, A.R.; Siegbahn, A.; Spector, T.D.; Stefansson, K.; Strachan, D.P.; Tayo, B.O.; Tremoli, E.; Tuomilehto, J.; Uusitupa, M.; van Duijn, C.M.; Vollenweider, P.; Wallentin, L.; Wareham, N.J.; Whitfield, J.B.; Wolffenbuttel, B.H.; Ordovas, J.M.; Boerwinkle, E.; Palmer, C.N.; Thorsteinsdottir, U.; Chasman, D.I.; Rotter, J.I.; Franks, P.W.; Ripatti, S.; Cupples, L.A.; Sandhu, M.S.; Rich, S.S.; Boehnke, M.; Deloukas, P.; Kathiresan, S.; Mohlke, K.L.; Ingelsson, E.; Abecasis, G.R.

doi:10.1038/ng.2797

Discovery and refinement of loci associated with lipid levels.

Details

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Serval ID

serval:BIB_4F479093D7BD

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Discovery and refinement of loci associated with lipid levels.

Journal

Nature Genetics

Author(s)

Willer C.J., Willer C.J., Schmidt E.M., Sengupta S., Peloso G.M., Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich M.L., Mora S., Beckmann J.S., Bragg-Gresham J.L., Chang H.Y., Demirkan A., Den Hertog H.M., Do R., Donnelly L.A., Ehret G.B., Esko T., Feitosa M.F., Ferreira T., Fischer K., Fontanillas P., Fraser R.M., Freitag D.F., Gurdasani D., Heikkilä K., Hyppönen E., Isaacs A., Jackson A.U., Johansson A., Johnson T., Kaakinen M., Kettunen J., Kleber M.E., Li X., Luan J., Lyytikäinen L.P., Magnusson P.K., Mangino M., Mihailov E., Montasser M.E., Müller-Nurasyid M., Nolte I.M., O'Connell J.R., Palmer C.D., Perola M., Petersen A.K., Sanna S., Saxena R., Service S.K., Shah S., Shungin D., Sidore C., Song C., Strawbridge R.J., Surakka I., Tanaka T., Teslovich T.M., Thorleifsson G., Van den Herik E.G., Voight B.F., Volcik K.A., Waite L.L., Wong A., Wu Y., Zhang W., Absher D., Asiki G., Barroso I., Been L.F., Bolton J.L., Bonnycastle L.L., Brambilla P., Burnett M.S., Cesana G., Dimitriou M., Doney A.S., Döring A., Elliott P., Epstein S.E., Eyjolfsson G.I., Gigante B., Goodarzi M.O., Grallert H., Gravito M.L., Groves C.J., Hallmans G., Hartikainen A.L., Hayward C., Hernandez D., Hicks A.A., Holm H., Hung Y.J., Illig T., Jones M.R., Kaleebu P., Kastelein J.J., Khaw K.T., Kim E., Klopp N., Komulainen P., Kumari M., Langenberg C., Lehtimäki T., Lin S.Y., Lindström J., Loos R.J., Mach F., McArdle W.L., Meisinger C., Mitchell B.D., Müller G., Nagaraja R., Narisu N., Nieminen T.V., Nsubuga R.N., Olafsson I., Ong K.K., Palotie A., Papamarkou T., Pomilla C., Pouta A., Rader D.J., Reilly M.P., Ridker P.M., Rivadeneira F., Rudan I., Ruokonen A., Samani N., Scharnagl H., Seeley J., Silander K., Stancáková A., Stirrups K., Swift A.J., Tiret L., Uitterlinden A.G., van Pelt L.J., Vedantam S., Wainwright N., Wijmenga C., Wild S.H., Willemsen G., Wilsgaard T., Wilson J.F., Young E.H., Zhao J.H., Adair L.S., Arveiler D., Assimes T.L., Bandinelli S., Bennett F., Bochud M., Boehm B.O., Boomsma D.I., Borecki I.B., Bornstein S.R., Bovet P., Burnier M., Campbell H., Chakravarti A., Chambers J.C., Chen Y.D., Collins F.S., Cooper R.S., Danesh J., Dedoussis G., de Faire U., Feranil A.B., Ferrières J., Ferrucci L., Freimer N.B., Gieger C., Groop L.C., Gudnason V., Gyllensten U., Hamsten A., Harris T.B., Hingorani A., Hirschhorn J.N., Hofman A., Hovingh G.K., Hsiung C.A., Humphries S.E., Hunt S.C., Hveem K., Iribarren C., Järvelin M.R., Jula A., Kähönen M., Kaprio J., Kesäniemi A., Kivimaki M., Kooner J.S., Koudstaal P.J., Krauss R.M., Kuh D., Kuusisto J., Kyvik K.O., Laakso M., Lakka T.A., Lind L., Lindgren C.M., Martin N.G., März W., McCarthy M.I., McKenzie C.A., Meneton P., Metspalu A., Moilanen L., Morris A.D., Munroe P.B., Njølstad I., Pedersen N.L., Power C., Pramstaller P.P., Price J.F., Psaty B.M., Quertermous T., Rauramaa R., Saleheen D., Salomaa V., Sanghera D.K., Saramies J., Schwarz P.E., Sheu W.H., Shuldiner A.R., Siegbahn A., Spector T.D., Stefansson K., Strachan D.P., Tayo B.O., Tremoli E., Tuomilehto J., Uusitupa M., van Duijn C.M., Vollenweider P., Wallentin L., Wareham N.J., Whitfield J.B., Wolffenbuttel B.H., Ordovas J.M., Boerwinkle E., Palmer C.N., Thorsteinsdottir U., Chasman D.I., Rotter J.I., Franks P.W., Ripatti S., Cupples L.A., Sandhu M.S., Rich S.S., Boehnke M., Deloukas P., Kathiresan S., Mohlke K.L., Ingelsson E., Abecasis G.R.

Working group(s)

Global Lipids Genetics Consortium

ISSN

1546-1718 (Electronic)

ISSN-L

1061-4036

Publication state

Published

Issued date

2013

Volume

Number

Pages

1274-1283

Language

english

Notes

Publication types: Journal ArticlePublication Status: ppublish. J.S. Beckmann, M. Bochud, P. Bovet, M. Burnier et P. Vollenweider font partie de Global Lipids Genetics Consortium

Abstract

Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

URN

urn:nbn:ch:serval-BIB_4F479093D7BD1

OAI-PMH

oai:serval.unil.ch:BIB_4F479093D7BD

DOI

10.1038/ng.2797

Pubmed

24097068

Web of science

000326384100007

Create date

10/12/2013 11:42