Mesenchymal stromal cells in cancer: a review of their immunomodulatory functions and dual effects on tumor progression.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_336DFF871F9C
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Mesenchymal stromal cells in cancer: a review of their immunomodulatory functions and dual effects on tumor progression.
Journal
The Journal of pathology
Author(s)
Galland S., Stamenkovic I.
ISSN
1096-9896 (Electronic)
ISSN-L
0022-3417
Publication state
Published
Issued date
04/2020
Peer-reviewed
Oui
Volume
250
Number
5
Pages
555-572
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Mesenchymal stem or stromal cells (MSCs) are pluripotent cells implicated in a broad range of physiological events, including organogenesis and maintenance of tissue homeostasis as well as tissue regeneration and repair. Because their current definition is somewhat loose - based primarily on their ability to differentiate into a variety of mesenchymal tissues, adhere to plastic, and express, or lack, a handful of cell surface markers - MSCs likely encompass several subpopulations, which may have diverse properties. Their diversity may explain, at least in part, the pleiotropic functions that they display in different physiological and pathological settings. In the context of tissue injury, MSCs can respectively promote and attenuate inflammation during the early and late phases of tissue repair. They may thereby act as sensors of the inflammatory response and secrete mediators that boost or temper the response as required by the stage of the reparatory and regenerative process. MSCs are also implicated in regulating tumor development, in which they are increasingly recognized to play a complex role. Thus, MSCs can both promote and constrain tumor progression by directly affecting tumor cells via secreted mediators and cell-cell interactions and by modulating the innate and adaptive immune response. This review summarizes our current understanding of MSC involvement in tumor development and highlights the mechanistic underpinnings of their implication in tumor growth and progression. © 2020 Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Keywords
Cell Communication/physiology, Disease Progression, Humans, Inflammation/pathology, Mesenchymal Stem Cell Transplantation/methods, Mesenchymal Stem Cells/immunology, Mesenchymal Stem Cells/pathology, Neoplasms/pathology, Toll-like receptors, anti-tumor therapy, cancer, exosomes, immune system, inflammation, interleukin-6, mesenchymal stem/stromal cells
Pubmed
Web of science
Open Access
Yes
Create date
15/10/2019 11:50
Last modification date
23/01/2024 8:22
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