Olfactory Receptor Gene Regulation in Insects: Multiple Mechanisms for Singular Expression.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_21813417D0E8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Olfactory Receptor Gene Regulation in Insects: Multiple Mechanisms for Singular Expression.
Journal
Frontiers in neuroscience
Author(s)
Mika K., Benton R.
ISSN
1662-4548 (Print)
ISSN-L
1662-453X
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
15
Pages
738088
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
The singular expression of insect olfactory receptors in specific populations of olfactory sensory neurons is fundamental to the encoding of odors in patterns of neuronal activity in the brain. How a receptor gene is selected, from among a large repertoire in the genome, to be expressed in a particular neuron is an outstanding question. Focusing on Drosophila melanogaster, where most investigations have been performed, but incorporating recent insights from other insect species, we review the multilevel regulatory mechanisms of olfactory receptor expression. We discuss how cis-regulatory elements, trans-acting factors, chromatin modifications, and feedback pathways collaborate to activate and maintain expression of the chosen receptor (and to suppress others), highlighting similarities and differences with the mechanisms underlying singular receptor expression in mammals. We also consider the plasticity of receptor regulation in response to environmental cues and internal state during the lifetime of an individual, as well as the evolution of novel expression patterns over longer timescales. Finally, we describe the mechanisms and potential significance of examples of receptor co-expression.
Keywords
Drosophila, evolution, feedback, gene expression, insects, neurodevelopment, olfactory receptor, sensory neuron
Pubmed
Web of science
Open Access
Yes
Create date
30/06/2021 14:45
Last modification date
12/01/2022 7:08
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