Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis.

Gunasekera, B.; Davies, C.; Blest-Hopley, G.; Veronese, M.; Ramsey, N.F.; Bossong, M.G.; Radua, J.; Bhattacharyya, S.

doi:10.1016/j.neubiorev.2022.104801

Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis.

Details

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Serval ID

serval:BIB_1BBAB7FDA7B2

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis.

Journal

Neuroscience and biobehavioral reviews

Author(s)

Gunasekera B., Davies C., Blest-Hopley G., Veronese M., Ramsey N.F., Bossong M.G., Radua J., Bhattacharyya S.

Working group(s)

CBE Consortium

Contributor(s)

Pretzsch C., McAlonan G., Walter C., Lötsch J., Freeman T., Curran V., Battistella G., Fornari E., Filho G.B., Crippa J.A., Duran F., Zuardi A.W.

ISSN

1873-7528 (Electronic)

ISSN-L

0149-7634

Publication state

Published

Issued date

09/2022

Peer-reviewed

Oui

Volume

140

Pages

104801

Language

english

Notes

Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish

Abstract

The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called 'activation signal') in a 'core' network of brain regions from 372 participants, tested using a within-subject repeated measures design under experimental conditions. We also investigated whether the neuromodulatory effects of THC are related to the local expression of the cannabinoid-type-1 (CB1R) and type-2 (CB2R) receptors. Finally, we investigated the dose-response relationship between THC and key brain substrates. These meta-analytic findings shed new light on the localisation of the effects of THC in the human brain, suggesting that THC has neuromodulatory effects in regions central to many cognitive tasks and processes, related to dose, with greater effects in regions with higher levels of CB1R expression.

Keywords

Brain, Dronabinol, Gene Expression, Humans, Neuroimaging, Receptors, Cannabinoid, Regression Analysis, Attention, Cannabis, FMRI, Memory, Meta-analysis, PET, Reward, Systematic, THC, Tetrahydrocannabinol

URN

urn:nbn:ch:serval-BIB_1BBAB7FDA7B21

OAI-PMH

oai:serval.unil.ch:BIB_1BBAB7FDA7B2

DOI

10.1016/j.neubiorev.2022.104801

Pubmed

35914625

Web of science

000851378200007

Open Access

Yes