Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus.

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_09DF59F4E89B
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus.
Journal
Future virology
Author(s)
Cattaneo A.M.
ISSN
1746-0794 (Print)
ISSN-L
1746-0794
Publication state
Published
Issued date
03/2022
Peer-reviewed
Oui
Volume
0
Number
0
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Several investigations suggested origins of SARS-CoV-2 from the recombination of coronaviruses of various animals, including the bat Rhinolophus affinis and the pangolin Manis javanica, despite the processes describing the adaptation from a reservoir of animals to human are still debated. In this perspective, I will remark two main inconsistencies on the origins of SARS-CoV-2: polypeptide sequence alignment of the S-proteins does not return the expected identity of the receptor-binding motif among most of pangolin-CoVs and SARS-CoV-2; accurate referencing for samplings and sequencing deposition of the ancestral bat coronavirus named RaTG13 was missing since the first reports on the SARS-CoV-2 coronavirus. This contribution aims to stimulate discussion about the origins of SARS-CoV-2 and considers other intermediate hosts as a reservoir for coronavirus.
Keywords
RaTG13, S-protein, SARS-CoV-2, coronavirus, polypeptide sequence alignment, receptor-binding motif
Pubmed
Web of science
Create date
22/04/2022 18:41
Last modification date
23/01/2024 8:20
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