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doi:10.22028/D291-26340
Titel: | Fully automated segmentation and morphometrical analysis of muscle fibre images |
VerfasserIn: | Kim, Yoo-Jin Brox, Thomas Feiden, Wolfgang Weickert, Joachim |
Sprache: | Englisch |
Erscheinungsjahr: | 2006 |
Freie Schlagwörter: | automated morphometry image analysis segmentation muscle fibre size |
DDC-Sachgruppe: | 510 Mathematik |
Dokumenttyp: | Sonstiges |
Abstract: | Background Measurement of muscle fibre size and determination of size distribution is important in the assessment of neuromuscular disease. Fibre size estimation by simple inspection is inaccurate and subjective. Manual segmentation and measurement are time-consuming and tedious. We therefore propose an automated image analysis method for objective, reproducible, and time-saving measurement of muscle fibres in routinely hematoxylin-eosin stained cryostat sections. Methods The proposed segmentation technique makes use of recent advances in level set based segmentation, where classical edge based active contours are extended by region based cues, such as colour and texture. Segmentation and measurement are performed fully automatically. Multiple morphometric parameters, i.e., cross sectional area, lesser diameter, and perimeter are assessed in a single pass. The performance of the computed method was compared to results obtained by manual measurement by experts. Results The correct classification rate of the computed method was high (98%). Segmentation and measurement results obtained manually or automatically did not reveal any significant differences. Conclusions The presented region based active contour approach has been proven to accurately segment and measure muscle fibres. Complete automation minimises user interaction, thus, batch processing, as well as objective and reproducible muscle fibre morphometry are provided. |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291-scidok-46648 hdl:20.500.11880/26396 http://dx.doi.org/10.22028/D291-26340 |
Schriftenreihe: | Preprint / Fachrichtung Mathematik, Universität des Saarlandes |
Band: | 177 |
Datum des Eintrags: | 13-Mär-2012 |
Fakultät: | MI - Fakultät für Mathematik und Informatik |
Fachrichtung: | MI - Mathematik |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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preprint_177_06.pdf | 1,22 MB | Adobe PDF | Öffnen/Anzeigen |
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