Twenty years of active bat rabies surveillance in Germany

  • In Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics andIn Germany, active bat rabies surveillance was conducted between 1993 and 2012. A total of 4546 oropharyngeal swab samples from 18 bat species were screened for the presence of EBLV-1- , EBLV-2- and BBLV-specific RNA. Overall, 0 center dot 15% of oropharyngeal swab samples tested EBLV-1 positive, with the majority originating from Eptesicus serotinus. Interestingly, out of seven RT-PCR-positive oropharyngeal swabs subjected to virus isolation, viable virus was isolated from a single serotine bat (E. serotinus). Additionally, about 1226 blood samples were tested serologically, and varying virus neutralizing antibody titres were found in at least eight different bat species. The detection of viral RNA and seroconversion in repeatedly sampled serotine bats indicates long-term circulation of the virus in a particular bat colony. The limitations of random-based active bat rabies surveillance over passive bat rabies surveillance and its possible application of targeted approaches for future research activities on bat lyssavirus dynamics and maintenance are discussed.show moreshow less

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Author details:Juliane Schatz, Bernd Ohlendorf, Peter Busse, Gerrit Pelz, Dietrich Dolch, Jens Teubner, Jorge A. EncarnacaoORCiD, Ralf-Udo Mühle, M. Fischer, Bernd Hoffmann, Linda Kwasnitschka, Anne Balkema-Buschmann, Thomas Christoph Mettenleiter, T. Müller, Conrad M. Freuling
URN:urn:nbn:de:kobv:517-opus4-415140
DOI:https://doi.org/10.25932/publishup-41514
ISSN:1866-8364
Title of parent work (English):Postprints der Universität Potsdam Humanwissenschaftliche Reihe
Subtitle (English):a detailed analysis and future perspectives
Publication series (Volume number):Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe (533)
Publication type:Postprint
Language:English
Date of first publication:2019/02/14
Publication year:2013
Publishing institution:Universität Potsdam
Release date:2019/02/14
Tag:Bat rabies; epidemiology; lyssavirus; surveillance
Issue:533
Number of pages:12
Source:Epidemiology and Infection 142 (2014) 6, S. 1155–1166 DOI: 10.1017/S0950268813002185
Organizational units:Humanwissenschaftliche Fakultät
DDC classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Peer review:Referiert
Publishing method:Open Access
Grantor:Cambridge University Press (CUP)
License (German):License LogoKeine öffentliche Lizenz: Unter Urheberrechtsschutz
External remark:Bibliographieeintrag der Originalveröffentlichung/Quelle
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