The role of conventional TACE (cTACE) and DEBIRI-TACE in colorectal cancer liver metastases

  • Colorectal cancer (CRC) is one of the most common tumor entities worldwide and a common cause of cancer-associated death. Colorectal cancer liver metastases (CRLM) thereby constitute a severe life-limiting factor. The therapy of CRLM presents a major challenge and surgical resection as well as systemic chemotherapy remain the first-line treatment options. Over the years several locoregional, vascular- and image-based treatments offered by interventional radiologists have emerged when conventional therapies fail, or metastases recurrence occurs. Among such options is the conventional/traditional transarterial chemoembolization (cTACE) by local injection of a combination of chemotherapeutic- and embolic-agents. A similar treatment is the more recent irinotecan-loaded drug-eluting beads TACE (DEBIRI-TACE), which are administered using the same approach. Numerous studies have shown that these different types of chemoembolization can be applied in different clinical settings safely. Furthermore, such treatments can also be combined with other local or systemic therapies. Unfortunately, due to the incoherent patient populations of studies investigating TACE in CRLM, critics state that the definite evidence supporting positive patient outcomes is still lacking. In the following article we review studies on conventional and DEBIRI-TACE. Although highly dependent on the clinical setting, prior therapies and generally the study population, cTACE and DEBIRI-TACE show comparable results. We present the most representative studies on the different chemoembolization procedures and compare the results. Although there is compelling evidence for both approaches, further studies are necessary to determine which patients profit most from these therapies. In conclusion, we determine TACE to be a viable option in CRLM in different clinical settings. Nevertheless, a multidisciplinary approach is desired to offer patients the best possible care.

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Author:Thomas J. VoglORCiDGND, Maximilian LahrsowORCiDGND
URN:urn:nbn:de:hebis:30:3-819419
DOI:https://doi.org/10.3390/cancers14061503
ISSN:2072-6694
Parent Title (English):Cancers
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2022/03/15
Date of first Publication:2022/03/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/02/13
Tag:colorectal cancer (CRC); colorectal cancer liver metastases (CRLM); conventional/traditional transarterial chemoembolization (cTACE); drug-eluting beads TACE (DEB-TACE); irinotecan-loaded drug-eluting beads TACE (DEBIRI-TACE); overall survival (OS); progression-free survival (PFS)
Volume:14
Issue:6, art. 1503
Article Number:1503
Page Number:11
First Page:1
Last Page:11
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International