Pascal Aggensteiner, Björn Albrecht, Ute Strehl, Sonja Wörz, Christian Rainer Ruckes, Christine M. Freitag, Aribert Rothenberger, Holger Gevensleben, Sabina Millenet, Sarah Hohmann, Tobias Banaschewski, Tanja Legenbauer, Martin Holtmann, Daniel Brandeis
- Abstract: Neurophysiological measures of preparation and attention are often atypical in ADHD. Still, replicated findings that these measures predict which patients improve after Neurofeedback (NF), reveal neurophysiological specificity, and reflect ADHD-severity are limited. Methods: We analyzed children’s preparatory (CNV) and attentional (Cue-P3) brain activity and behavioral performance during a cued Continuous Performance Task (CPT) before and after slow cortical potential (SCP)-NF or semi-active control treatment (electromyogram biofeedback). Mixed-effects models were performed with 103 participants at baseline and 77 were assessed for pre-post comparisons focusing on clinical outcome prediction, specific neurophysiological effects of NF, and associations with ADHD-severity. Results: Attentional and preparatory brain activity and performance were non-specifically reduced after treatment. Preparatory activity in the SCP-NF group increased with clinical improvement. Several performance and brain activity measures predicted non-specific treatment outcome. Conclusion: Specific neurophysiological effects after SCP-NF were limited to increased neural preparation associated with improvement on ADHD-subscales, but several performance and neurophysiological measures of attention predicted treatment outcome and reflected symptom severity in ADHD. The results may help to optimize treatment.
Metadaten| Author: | Pascal AggensteinerORCiDGND, Björn AlbrechtORCiDGND, Ute StrehlORCiDGND, Sonja WörzGND, Christian Rainer RuckesGND, Christine M. FreitagORCiDGND, Aribert RothenbergerORCiDGND, Holger Gevensleben, Sabina MillenetORCiDGND, Sarah HohmannORCiDGND, Tobias BanaschewskiORCiDGND, Tanja LegenbauerORCiDGND, Martin HoltmannORCiDGND, Daniel BrandeisGND |
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| URN: | urn:nbn:de:hebis:30:3-644263 |
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| DOI: | https://doi.org/10.1016/j.biopsycho.2021.108169 |
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| ISSN: | 1873-6246 |
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| Parent Title (English): | Biological psychology |
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| Publisher: | Elsevier Science |
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| Place of publication: | Amsterdam [u.a.] |
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| Document Type: | Article |
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| Language: | English |
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| Date of Publication (online): | 2021/08/18 |
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| Date of first Publication: | 2021/08/18 |
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| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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| Release Date: | 2022/01/21 |
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| Tag: | Attention-Deficit/Hyperactivity Disorder (ADHD); Contingent Negative Variation, CNV; Continuous Performance Test, CPT; Cue-P3; Event related potentials; Neurofeedback; Randomized Controlled Trial; Response control; Slow Cortical Potentials, SCP; Sustained attention |
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| Volume: | 165 |
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| Issue: | art. 108169 |
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| Page Number: | 12 |
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| First Page: | 1 |
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| Last Page: | 12 |
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| Note: | This study was funded by the German Research Foundation DFG HO 2503/4-1 and 2503/4-2. The funding body had no influence on the study design, collection, analysis and interpretation of data, the writing of the report, or the decision to submit the paper for publication. |
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| HeBIS-PPN: | 491292090 |
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| Institutes: | Medizin |
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| Dewey Decimal Classification: | 1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie |
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| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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| Sammlungen: | Universitätspublikationen |
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| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
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Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0