Unbiased translation proteomics upon cell stress
- The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently described a new method for quantitative translation proteomics and found that both pathways control translation of the same sets of proteins.
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| Author: | Kevin KlannORCiDGND, Christian MünchORCiD |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-625672 |
| DOI: | https://doi.org/10.1080/23723556.2020.1763150 |
| ISSN: | 2372-3556 |
| Parent Title (English): | Molecular & cellular oncology |
| Publisher: | Taylor & Francis |
| Place of publication: | London |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/05/18 |
| Date of first Publication: | 2020/05/18 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2022/03/07 |
| Tag: | ISR; Translation proteomics; integrated stress response; mTOR; proteostasis; stress; translatome |
| Volume: | 7 |
| Issue: | 4, art. e1763150 |
| Page Number: | 2 |
| First Page: | 1 |
| Last Page: | 2 |
| Note: | C.M. was supported by the European Research Council (ERC StG 803565), the Emmy Noether Program (DFG, MU 4216/1-1), and the Johanna Quandt Young Academy at Goethe. |
| HeBIS-PPN: | 492096708 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
