Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis
- Objective: The mortality associated with sepsis remains unacceptably high, despite modern high-quality intensive care. Based on the results from previous studies, anaemia and its management in patients with sepsis appear to impact outcomes; however, the transfusion policy is still being debated, and the ideal approach may be extremely specific to the individual. This study aimed to investigate the long-term impact of anaemia requiring red blood cell (RBC) transfusion on mortality and disease severity in patients with sepsis. We studied a general surgical intensive care unit (ICU) population, excluding cardiac surgery patients. 435 patients were enrolled in this observational study between 2012 and 2016. Results: Patients who received RBC transfusion between 28 days before and 28 days after the development of sepsis (n = 302) exhibited a significantly higher 90-day mortality rate (34.1% vs 19.6%; P = 0.004, Kaplan–Meier analysis). This association remained significant after adjusting for confounders in the multivariate Cox regression analysis (hazard ratio 1.68; 95% confidence interval 1.03–2.73; P = 0.035). Patients who received transfusions also showed significantly higher morbidity scores, such as SOFA scores, and ICU lengths of stay compared to patients without transfusions (n = 133). Our results indicate that anaemia and RBC transfusion are associated with unfavourable outcomes in patients with sepsis.
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| Author: | Katalin Kristof, Benedikt Büttner, Anna Grimm, Caspar Mewes, Bastian SchmackGND, Aron-Frederik Popov, Michael GhadimiORCiDGND, Tim Beißbarth, José-Maria Hinz, Ingo Bergmann, Ashham Mansur |
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| URN: | urn:nbn:de:hebis:30:3-500515 |
| DOI: | https://doi.org/10.1186/s13104-018-3988-z |
| ISSN: | 1756-0500 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/30537993 |
| Parent Title (English): | BMC Research Notes |
| Publisher: | Biomed Central |
| Place of publication: | London |
| Document Type: | Article |
| Language: | English |
| Year of Completion: | 2018 |
| Date of first Publication: | 2018/12/11 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2019/04/25 |
| Tag: | Morbidity; Mortality; Organ dysfunction; Organ support; Red blood cell transfusion; Sepsis; Surgical ICU; Survival |
| Volume: | 11 |
| Issue: | 1, Art. 879 |
| Page Number: | 7 |
| First Page: | 1 |
| Last Page: | 7 |
| Note: | Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| HeBIS-PPN: | 450690008 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
