Expression of interleukin-18 receptor in fibroblast-like synoviocytes
- An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R alpha-chain and beta-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E2, or nitric oxide. We conclude that the presence of macrophages or IL-18R+ T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA. Open Access: Published: 14 November 2001 © 2002 Möller et al., licensee BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913)
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| Author: | Burkhard Möller, Uta Kessler, Stefan RehartORCiDGND, Uwe Kalina, Oliver G. OttmannORCiDGND, Joachim Peter KaltwasserGND, Dieter HoelzerGND, Natasa Kukoc-Zivojnov |
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| URN: | urn:nbn:de:hebis:30-11599 |
| DOI: | https://doi.org/10.1186/ar390 |
| ISSN: | 1465-9913 |
| ISSN: | 1478-6362 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/11879550 |
| Parent Title (English): | Arthritis Research & Therapy |
| Publisher: | BioMed Central |
| Place of publication: | London |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2005/06/22 |
| Date of first Publication: | 2001/11/14 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2005/06/22 |
| Tag: | fibroblast; interleukin-18; receptor; rheumatoid arthritis; synoviocyte |
| Volume: | 4 |
| Issue: | 2, Art. 139 |
| Page Number: | 8 |
| First Page: | 139 |
| Last Page: | 144 |
| Note: | © 2002 Möller et al., licensee BioMed Central Ltd |
| HeBIS-PPN: | 358651174 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Licence (German): |  Deutsches Urheberrecht |
