Publikationsserver der Universitätsbibliothek Marburg
Titel:Veränderung der Messergebnisse der quantitativen Ultrasonometrie (QUS) am Os calcaneusim Verlaufe der Schwangerschaft
Autor:Hahn, Birgit Renate Lieselotte
Weitere Beteiligte: Hadji, Peyman (Prof. Dr. med.)
Veröffentlicht:2016
URI:https://archiv.ub.uni-marburg.de/diss/z2017/0008
URN: urn:nbn:de:hebis:04-z2017-00081
DOI: https://doi.org/10.17192/z2017.0008
DDC: Medizin
Titel (trans.):Changes of measurements of quantitative ultrasonometry (QUS)in the calcaneal bone during pregnancy
Publikationsdatum:2017-01-17
Lizenz:https://creativecommons.org/licenses/by/4.0

Dokument

Schlagwörter:
Osteoporosis, Knochenstoffwechsel, Bone Mass Loss, Schwangerschaft, Pregnancy, Knochendichteminderung, Osteoporose

Zusammenfassung:
Die vorliegende Studie konnte einen signifikanten Abfall des T-Score und Steifigkeitsindexes (SI) im Verlauf der Schwangerschaft vom zweiten zum dritten Trimester nachweisen. Dies geht einher mit einem erhöhten Bedarf an Kalzium und folgendem Verlust an Knochendichte (BMD) während der Hochphase fetalen Wachstums am Ende der Schwangerschaft. Junge Primiparae ohne anamnestische körperliche Betätigung zeigten dabei Ultraschallmesswerte, die auf das höchste Risiko für Knochenfrakturen hindeuteten. Eine mögliche spätere Normalisierung der Messwerte weist dabei auf mögliche molekulare und biochemische Mechanismen hin, die Gegenstand weiteren Untersuchungen bleiben müssen.

Bibliographie / References

  1. 112. Phillips, A.J., S.J. Ostlere, R. Smith Pregnancy-associated osteoporosis: does the skeleton recover? Osteoporosis Int 2000;11(5):449-54 DOI: 10.1007.10912848
  2. 89. Kovacs, C.S., Calcium and Bone Metabolism in Pregnancy and Lactation JCFM, June 1, 2001;86(6):2344-2348 DOI: 10.1210/jc.86.6.2344
  3. 113. Ritchie LD., Fung EB., Halloran BP, Turnlund JR., Vann l., Cann CE., King JC. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses Am.J.Clin.Nutr. 1998; 67 (4): 693-701
  4. 119. Schneider, S. Auswirkungen der Schwangerschaft auf die mittels Ultrasonometrie bestimmte Knochendichte Inauguraldissertation Universität Tübingen 2009
  5. 98. More, C., P. Bettembuk, H.P. Bhattoa, A. Balogh The Effects of Pregnancy and Lactation on Bone Mineral Density Osteoporos Int. (2001) 12: 732-737
  6. 93. Lissner l, Bengtsson C, Hansson T Bone mineral content in relation to lactation history in pre- and postmenopausal women Calcif Tissue Int 1991; 48:319
  7. 90. Krebs NF, Reidinger CJ, Robertson AD, Brenner M Bone mineral density changes during lactation: maternal dietary and biochemical correlates Am J Clin Nutr 1997; 65:1738
  8. 96. Mahadevan, S., V. Kumaravel, R. Bharath Calcium and bone disorders in pregnancy Indian J Endocr Metab 2012;16:358-63
  9. 88. Kovacs, C.S., G.E.H. Fuleihan Calcium and bone disorders during pregnancy and lactation Endocrinol Metab Clin N Am 2006;35:21-51
  10. 101. Nevitt, MC., SR. Cummings, KL. Stone, L.Palermo, DM. Black, DC. Bauer, HK. Genant, MC. Hochberg, KE. Ensrud, TA. Hillier, JA. Cauley Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fractures J.Bone Miner.Res. 2005; 20 (1): 131-140
  11. 97. Møller UK, Streym S, Mosekilde L Changes in bone mineral density and body composition during pregnancy and postpartum. A controlled cohort study Osteoporos Int 2012; 23: 1213-1223
  12. 92. Lamke B, Brundin J, Moberg P. Changes of bone mineral content during pregnancy and lactation
  13. 107. Okyay DO, Okyay E, Dogan E, Kurtulmus S, Acet F, Eftal Taner, C Prolonged breast-feeding is an independent risk factor for postmenopausal osteoporosis Maturitas 2014; 77 (3): 249-54
  14. 115. Rubin, LA., GA. Hawker, VD. Peltekova, LJ Fielding, R. Ridout, DE. Cole Determinants of peak bone mass: clinical and genetic analyses in a young female Canadian cohort J. Bone Miner. Res. 1999; 14 (4): 633-643
  15. 100. Naylor, K.E., P. Iqbal, C. Fledelius, R.B. Fraser, R. Eastell The effect of pregnancy on bone density and bone turnover J Bone Miner Res 2000 Jan;15(1):129-37
  16. 118. Schnabel M., G. Eser,V. Ziller, D. Mann, E. Mann, P. Hadji Bone mineral density in postmenopausal women with proximal femoral fractures-comparative study between quantitative ultrasonometry and gold standard DXA Zentralbl Chir.2005 Oct; 130(5): 469-75
  17. 91. Kyvernitakis I, Saeger U, Ziller V, Bauer,T, Seger-Pektas B, P. Hadji The effect of Age, Sex Hormones and Bone Turnover Markers on Calcaneal Quantitative Ultrasonometry in Healthy German Men J Clin Densit.2013, in press.
  18. 110. Pearson D., M. Kaur, P. San, N. Lawson, P. Baker, D. Hosking Recovery of pregnancy mediated bone loss during lactation Bone 2004 Mar;34(3):570-8
  19. 116. Sambrook PN, Cameron ID, Chen JS, Cumming RG, Lord SR, March LM, Schwarz J, Seibel MJ, Simpson JM Influence of fall related factors and bone strength on fracture risk in the frail elderly
  20. 105. Oleksik, A., P. Lips, A. Dawson, ME. Minshall, W.Shen, C. Cooper, J. Kanis Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures Miner.Res. 2000; 15 (7): 1384-1392
  21. 87. Kovacs, C.S., H.M. Kronenberg Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium and Lactation Endocrine Reviews December 1, 1997;18(6): 832-87
  22. 114. Robbins, JA., AM. Schott, P. Garnero, PD Delmas, D. Hans, PJ. Meunier Risk factor for hip fracture in women with high BMD: EPIDOS study Osteoporos.Int. 2005; 16 (2): 149-154
  23. 117. Sarli, M., C. Hakim, P. Rey, J. Zanchetta Osteoporosis during pregnancy and lactation. Report of eight cases Medicina (B Aires). 2005;65(6):489-94
  24. 119a. Seki K., Wada S., Nagata N., Nagata I. Parathyroid hormone-related protein during pregnancy and the perinatal period. Gynecol.Obstet.Invest 1994; 37 (2): 83-86
  25. 111. P. Peris, N. Guardens, A Monegal, F. Pons, I. Martinez de Ros, J. MunozGomez, M.J. Osaka Pregnancy associated osteoporosis: the familial effect Clin.Exp.Rheumatol. 2002 Sept-Oct;20(5):697-700
  26. 95. Lübbe, K., H. Riedel Transiente regionale Osteoporose in der Schwangerschaft Geburtsh Frauenheilk 2000; 60(7): 380-385
  27. 120. Silbergeld, E.K., Lead in Bone: Implications for Toxicology during Pregnancy and Lactation Environmental Health Perspectives, 1991;91:63-70 131a. Uemura H., Yasui T., Kiyokawa M., Kuwahara A., Ikawa H.,Matsuzaki T., Maegawa M., Furumoto H., Irahara M. Serum osteoprotegerin/osteoclastogenesis-inhibitory factor during pregnancy and lactation and the relationship with calcium-regulating hormones and bone turnover markers. Endocrinol. 2002; 174(2): 353-359
  28. 109. Paton, L.M., J.L. Alexander, C.A. Nowson, C. Margerison, M.G. Frame, B. Kaymakci, J.D. Wark Pregnancy and lactation have no longterm deleterious effect on measure of bone mineral in healthy women: a twin study Am J Clin Nutr. 2003 Mar;77(3):707-14

* Das Dokument ist im Internet frei zugänglich - Hinweise zu den Nutzungsrechten
© UB Marburg 1997 - 2024 Universitätsbibliothek Marburg