Publikationsserver der Universitätsbibliothek Marburg

Titel:Noninvasive discrimination of patients with chronic obstructive pulmonary disease and alpha-1-antitrypsin deficiency using an electronic nose
Autor:Hattesohl, Akira
Weitere Beteiligte: Schmeck, Bernd (Prof. Dr.)
Veröffentlicht:2016
URI:https://archiv.ub.uni-marburg.de/diss/z2017/0006
URN: urn:nbn:de:hebis:04-z2017-00066
DOI: https://doi.org/10.17192/z2017.0006
DDC: Medizin
Titel (trans.):Nichtinvasive Diskriminierung von Patienten mit chronisch obstruktiver Lungenerkrankung und Alpha-1-Antrypsinmangel mittels einer elektronischen Nase
Publikationsdatum:2017-01-17
Lizenz:https://creativecommons.org/licenses/by-nc-nd/4.0/

Dokument

Schlagwörter:
Erbkrankheit, Pulmonologie, Elektronische Nase, Medizin, Obstruktive Ventilationsstörung, Alpha-1-Antitrypsinmangel, Diagnose, Diskriminierung, Atemluft, alpha-1-antitrypsin deficiency

Summary:
The aim of this thesis was to assess, if human exhaled breath of patients with chronic obstructive pulmonary disease (COPD) and of patients with alpha-1-antitrypsin deficiency (AATD), that resembles COPD, can be used for simplified, noninvasive, and cost-efficient diagnostic purposes using electronic nose technology.

Bibliographie / References

  1. 22. Bunkowski A, Maddula S, Davies AN, Westhoff M, Litterst P, Bödecker B, Baumbach JI (2010) One-year time series of investigations of analytes within human breath using ion mobility spectrometry. Int J Ion Mobil Spectrom 13:141-148. doi:10.1007/ s12127-010-0052-7
  2. 9. Jünger M, Bödeker B, Baumbach JI (2010) Peak assignment in multi-capillary column-ion mobility spectrometry using comparative studies with gas chromatography-mass spectrometry for exhaled breath analysis. Anal Bioanal Chem 396:471-482. doi:10.1007/s00216-009-3168-z
  3. 10. Bödecker B, Davies AN, Maddula S, Baumbach JI (2010) Biomarker validation-room air variation during human breath investigations. Int J Ion Mobil Spectrom 13:177-184. doi:10.1007/s12127-010-0044-7
  4. 7. Bessa V, Darwiche K, Teschler H, Sommerwerck U, Rabis T, Baumbach JI, Freitag L (2011) Detection of volatile organic compounds (VOCs) in exhaled breath of patients with chronic obstructive pulmonary disease (COPD) by ion mobility spectrometry. Int J Ion Mobil Spectrom 14:7-13. doi:10.1007/s12127-011-0060-2
  5. 4. Moser B, Bodrogi F, Eibl G, Lechner M, Rieder J, Lirk P (2005) Mass spectrometric profile of exhaled breath-field study by PTRMS. Respir Physiol Neurobiol 145:295-300. doi:10.1016/j. resp.2004.02.002
  6. 16. Basanta M et al (2010) Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst 135:315-320. doi:10.1039/b916 374c
  7. 11. Westhoff M, Litterst P, Freitag L, Urfer W, Bader S, Baumbach JI (2009) Ion mobility spectrometry for the detection of volatile organic compounds in exhaled breath of patients with lung cancer: results of a pilot study. Thorax 64:744-748. doi:10.1136/ thx.2008.099465
  8. 3. Fens N, Zwinderman AH, van der Schee MP, de Nijs SB, Dijkers E, Roldaan AC, Cheung D, Bel EH, Sterk PJ (2009) Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med 180:1076-1082. doi:10.1164/rccm.200906-0939OC
  9. 21 Montuschi P. Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications. Ther. Adv. Respir. Dis. 2007; 1: 5-23.
  10. 14. Ruzsanyi V, Baumbach JI (2005) Analysis of human breath using IMS. Int J Ion Mobil Spectrom 8:5-7
  11. 16 Dragonieri S, Schot R, Mertens BJ et al. An electronic nose in the discrimination of patients with asthma and controls. J. Allergy Clin. Immunol. 2007; 120: 856-62.
  12. 7 Dragonieri S, Annema JT, Schot R et al. An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer 2009; 64: 166-70.
  13. 15 D'Amico A, Pennazza G, Santonico M et al. An investigation on electronic nose diagnosis of lung cancer. Lung Cancer 2010; 68: 170-6.
  14. 30 Hubbard RC, McElvaney NG, Sellers SE et al. A-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency. J. Clin. Invest. 1989; 84: 1349-54.
  15. 27 Effros RM, Biller J, Foss B et al. A simple method for estimating respiratory solute dilution in exhaled breath condensates. Am. J. Respir. Crit. Care Med. 2003; 168: 1500-5.
  16. 11 Dutta R, Hines EL, Gardner JW et al. Bacteria classification using Cyranose 320 electronic nose. Biomed. Eng. Online 2002; 1: 4.
  17. 12 Shykhon ME, Morgan DW, Dutta R et al. Clinical evaluation of the electronic nose in the diagnosis of ear, nose and throat infection: a preliminary study. J. Laryngol. Otol. 2004; 118: 706-9.
  18. 5 Lewis NS. Comparisons between mammalian and artificial olfaction based on arrays of carbon black-polymer composite vapor detectors. Acc. Chem. Res. 2004; 37: 663-72.
  19. 15. Ruzsanyi V, Baumbach JI, Sielemann S, Litterst P, Westhoff M, Freitag L (2005) Detection of human metabolites using multicapillary columns coupled to ion mobility spectrometers. J Chromatogr A 1084:145-151
  20. 14 Machado RF, Laskowski D, Deffenderfer O et al. Detection of lung cancer by sensor array analyses of exhaled breath. Am. J. Respir. Crit. Care Med. 2005; 171: 1286-91.
  21. 23. Maddula S, Blank L, Schmid A, Baumbach JI (2009) Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry. Anal Bioanal Chem 394:791-800
  22. 13 Hockstein NG, Thaler ER, Torigian D et al. Diagnosis of pneumonia with an electronic nose: correlation of vapor signature with chest computed tomography scan findings. Laryngoscope 2004; 114: 1701-5.
  23. 8. Westhoff M, Litterst P, Maddula S, Bödecker B, Rahmann S, Davies AN, Baumbach JI (2010) Differentiation of chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control group by breath analysis using ion mobility spectrometry. Int J Ion Mobil Spectrom 13:131-139
  24. 23 Hoffmeyer F, Raulf-Heimsoth M, Bruning T. Exhaled breath condensate and airway inflammation. Curr. Opin. Allergy Clin. Immunol. 2009; 9: 16-22.
  25. 3 Fens N, Zwinderman AH, van der Schee MP et al. Exhaled breath profiling enables discrimination of chronic obstructive pulmonary disease and asthma. Am. J. Respir. Crit. Care Med. 2009; 180: 1076-82.
  26. 25 Montuschi P, Barnes PJ. Exhaled leukotrienes and prostaglandins in asthma. J. Allergy Clin. Immunol. 2002; 109: 615-20.
  27. 24 Kharitonov SA, Barnes PJ. Exhaled markers of inflammation. Curr. Opin. Allergy Clin. Immunol. 2001; 1: 217-24.
  28. 18 Malerba M, Ragnoli B, Radaeli A. Exhaled nitric oxide levels in alpha-1-antitrypsin PiMZ subjects. J. Intern. Med. 2009; 265: 382-7.
  29. 1 Rabe KF, Hurd S, Anzueto A et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med. 2007; 176: 532-55.
  30. 2 Bals R, Koczulla R, Kotke V et al. Identification of individuals with alpha-1-antitrypsin deficiency by a targeted screening program. Respir. Med. 2007; 101: 1708-14.
  31. 10 Lai SY, Deffenderfer OF, Hanson W et al. Identification of upper respiratory bacterial pathogens with the electronic nose. Laryngoscope 2002; 112: 975-9.
  32. 22 Carpagnano GE, Kharitonov SA, Resta O et al. Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest 2002; 122: 1162-7.
  33. 9 Baumbach JI. Ion mobility spectrometry coupled with multicapillary columns for metabolic profiling of human breath. J. Breath. Res. 2009; 3: 034001.
  34. 19. Westhoff M, Litterst P, Freitag L, Baumbach JI (2007) Ion mobility spectrometry in the diagnosis of Sarcoidosis: Results of a feasibility study. J Physiol Pharmacol 58:739-751
  35. 20. Baumbach JI, Westhoff M (2006) Ion mobility spectrometry to detect lung cancer and airway infections. Spectrosc Eur 18:22-27
  36. 26 Montuschi P, Martello S, Felli M et al. Liquid chromatography/ mass spectrometry analysis of exhaled leukotriene B4 in asthmatic children. Respir. Res. 2005; 6: 119.
  37. 19 Machado RF, Stoller JK, Laskowski D et al. Low levels of nitric oxide and carbon monoxide in alpha 1-antitrypsin deficiency. J. Appl. Physiol. 2002; 93: 2038-43.
  38. 4 Moser B, Bodrogi F, Eibl G et al. Mass spectrometric profile of exhaled breath-field study by PTR-MS. Respir. Physiol. Neurobiol. 2005; 145: 295-300.
  39. 12. Bunkowski A, Boedeker B, Bader S, Westhoff M, Litterst P, Baumbach JI (2009) MCC/IMS signals in human breath related to sarcoidosis-results of a feasibility study using an automated peak finding procedure. J Breath Res 3, 046001/046001-046001/ 046010
  40. 18. Gooptu B, Ekeowa UI, Lomas DA (2009) Mechanisms of emphysema in alpha1-antitrypsin deficiency: molecular and cellular insights. Eur Respir J 34(2):475-488
  41. 6 Thaler ER, Hanson CW. Medical applications of electronic nose technology. Expert Rev. Med. Devices 2005; 2: 559-66.
  42. 28 Montuschi P, Nightingale JA, Kharitonov SA et al. Ozoneinduced increase in exhaled 8-isoprostane in healthy subjects is resistant to inhaled budesonide. Free Radic. Biol. Med. 2002; 33: 1403-8.
  43. 26. Bödeker B, Vautz W, Baumbach JI (2008) Peak comparison in MCC/IMS-Data-Searching for potential biomarkers in human breath data. Int J Ion Mobil Spectrom 11:89-93
  44. 25. Bödeker B, Vautz W, Baumbach JI (2008) Peak finding and referencing in MCC/IMS-Data. Int J Ion Mobil Spectrom 11:83-88
  45. 21. Baumbach JI (2006) Process, analysis using ion mobility spectrometry. Anal Bioanal Chem 384:1059-1070
  46. 8 Holme J, Stockley RA. Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency. Chest 2007; 132: 909-15.
  47. 29 Dwyer TM. Sampling airway surface liquid: non-volatiles in the exhaled breath condensate. Lung 2004; 182: 241-50.
  48. 17. Basanta M, Koimtzis T, Thomas CLP (2006) Sampling and analysis of exhaled breath on human subjects with thermal desorption gas chromatography-differential mobility spectrometry. Int J Ion Mobil Spectrom 9:45-49
  49. 20 Woolhouse IS, Bayley DL, Stockley RA. Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8. Thorax 2002; 57: 709-14.
  50. 17 Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J. Clin. Invest. 2008; 118: 3546-56.
  51. 6. Wewers MD, Gadek JE (1987) The protease theory of emphysema. Ann Intern Med 107:761-763
  52. 31 Bossuyt PM, Reitsma JB. The STARD initiative. Lancet 2003;361: 71.


* Das Dokument ist im Internet frei zugänglich - Hinweise zu den Nutzungsrechten