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Titel:Carbonyl Reductases and Pluripotent HydroxysteroidDehydrogenases of the Short-Chain Dehydrogenase/ReductaseSuperfamily:Structural Aspects of Oligomerization in 3alpha-HydroxysteroidDehydrogenase /Carbonyl Reductase from Comamonas testosteroni:New Approaches for efficient Protein Design
Autor:Hoffmann-Geim, Frank
Weitere Beteiligte: Buckel, Wolfgang (Prof. Dr.)
Veröffentlicht:2009
URI:https://archiv.ub.uni-marburg.de/diss/z2009/0563
DOI: https://doi.org/10.17192/z2009.0563
URN: urn:nbn:de:hebis:04-z2009-05639
ISBN: 978-3-8366-3391-8
DDC: Biowissenschaften, Biologie
Titel (trans.):Carbonylreduktasen und pluripotente Hydroxysteroid Dehydrogenasen der Short-Chain Dehydrogenase/ Reduktase Superfamilie: Strukturell Aspekte der Oligomerisierung in 3 alpha-Hydroxysteroid Dehydrogenase/ Carbonyl Reduktase aus Comamonas testosteroni- Neue Ansätze für effizientes Protein Design
Publikationsdatum:2009-10-08
Lizenz:https://rightsstatements.org/vocab/InC-NC/1.0/

Dokument

Schlagwörter:
Simulation, Modellierung, Carbonyl-Reductase, Röntgenstruktur, Drug Design, Hydroxysteroid-Dehydrogenasen, SDR, SDR, Molekulardynamik, 3alpha HSD/CR, Molekulardynamik, Molecular dynamic, Hydroxysteroiddehydrogenase

Summary:
Carbonyl reduction of aldehydes, ketones and quinones to their corresponding hydroxy de-rivatives plays an important role in the phase-I metabolism of many endogenous (biogenic aldehydes, steroids, prostaglandins, reactive lipid peroxidation products) and xenobiotic (pharmacologic drugs, carcinogens, toxicants) compounds. Carbonyl-reducing enzymes are grouped into two large protein superfamilies, the aldo-keto reductases (AKR) and the short-chain dehydrogenases/reductases (SDR). Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs. In addition, there exist a variety of pluripotent hydroxysteroid dehydrogenases (HSDs) of both superfamilies which specifically catalyze the oxidoreduction at different positions of the steroid nucleus, and which also catalyze rather non-specifically the reductive metabolism of a great number of non-steroidal carbonyl compounds. The present review summarizes recent findings on car-bonyl reductases and pluripotent HSDs of the SDR protein superfamily.


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