Titel: | Mitogenic signaling by Gq/11-coupled receptors |
Autor: | Roelle, Susanne |
Weitere Beteiligte: | Carell, Thomas, Prof. Dr. |
Veröffentlicht: | 2004 |
URI: | https://archiv.ub.uni-marburg.de/diss/z2004/0120 |
DOI: | https://doi.org/10.17192/z2004.0120 |
URN: | urn:nbn:de:hebis:04-z2004-01207 |
DDC: | Chemie |
Publikationsdatum: | 2004-05-19 |
Lizenz: | https://rightsstatements.org/vocab/InC-NC/1.0/ |
Schlagwörter: |
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Neuropeptide, Zellproliferation, neuropeptides, cell proliferation, mitogenic signaling , phospholipase C, Mitogene Signalwege, Phospholipase C |
Summary:
By binding to their cognate GPCRs, many potent
mitogens such as neuropeptides, angiotensin II or
lysophosphatidic acid stimulate cell proliferation via engaging
the ERK/MAPK cascade. As mentioned before, agonists stimulating
Gq/11-coupled receptors activate PLCb isoforms thereby
activating PKCs and elevating [Ca2+]i. These two second
messengers represent key molecules for coupling Gq/11 proteins
to the ERK/MAPK cascade. In this work, by means of GnRH in
gonadotropic aT3-1 cells and galanin or bradykinin in SCLC
cells, different aspects of Gq/11-dependent mitogenic signaling
pathways were revealed. Our findings together with previous
reports underline the notion that signaling pathways emanating
from Gq/11-coupled receptors are tightly regulated in a cell-
and receptor-specific manner.
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