Aberrant network connectivity during error processing in patients with schizophrenia

BACKGROUND: Neuroimaging methods have pointed to deficits in the interaction of large-scale brain networks in patients with schizophrenia. Abnormal connectivity of the right anterior insula (AI), a central hub of the salience network, is frequently reported and may underlie patients’ deficits in ada...

Verfasser: Voegler, Rolf
Becker, Michael
Nitsch, Alexander M.
Miltner, Wolfgang
Straube, Thomas
FB/Einrichtung:FB 05: Medizinische Fakultät
Dokumenttypen:Artikel
Medientypen:Text
Erscheinungsdatum:2016
Publikation in MIAMI:09.11.2016
Datum der letzten Änderung:12.08.2019
Angaben zur Ausgabe:[Electronic ed.]
Quelle:Journal of Psychiatry and Neurosience 41 (2016) 2, E3-E12
Fachgebiet (DDC):610: Medizin und Gesundheit
Lizenz:InC 1.0
Sprache:English
Anmerkungen:Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF-Dokument
ISSN:1180-4882
URN:urn:nbn:de:hbz:6-84219574294
Weitere Identifikatoren:DOI: 10.1503/jpn.150092
Permalink:https://nbn-resolving.de/urn:nbn:de:hbz:6-84219574294
Onlinezugriff:41-2-E3.pdf

BACKGROUND: Neuroimaging methods have pointed to deficits in the interaction of large-scale brain networks in patients with schizophrenia. Abnormal connectivity of the right anterior insula (AI), a central hub of the salience network, is frequently reported and may underlie patients’ deficits in adaptive salience processing and cognitive control. While most previous studies used resting state approaches, we examined right AI interactions in a task-based fMRI study. METHODS: Patients with schizophrenia and healthy controls performed an adaptive version of the Eriksen Flanker task that was specifically designed to ensure a comparable number of errors between groups. RESULTS: We included 27 patients with schizophrenia and 27 healthy controls in our study. The between-groups comparison replicated the classic finding of reduced activation in the midcingulate cortex (MCC) in patients with schizophrenia during the commission of errors while controlling for confounding factors, such as task performance and error frequency, which have been neglected in many previous studies. Subsequent psychophysiological interaction analysis revealed aberrant functional connectivity (FC) between the right AI and regions in the inferior frontal gyrus and temporoparietal junction. Additionally, FC between the MCC and the dorsolateral prefrontal cortex was reduced. LIMITATIONS: As we examined a sample of medicated patients, effects of antipsychotic medication may have influenced our results. CONCLUSION: Overall, it appears that schizophrenia is associated with impairment of networks associated with detection of errors, refocusing of attention, superordinate guiding of cognitive control and their respective coordination.