Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP

Enterohemorrhagic E. coli (EHEC) causes severe diseases in humans worldwide. One of its virulence factors is EspP, which belongs to the serine protease autotransporters of Enterobacteriaceae (SPATE) family. In this review we recapitulate the current data on prevalence, biogenesis, structural propert...

Verfasser: Weiss, André
Brockmeyer, Jens
FB/Einrichtung:FB 12: Chemie und Pharmazie
Dokumenttypen:Artikel
Medientypen:Text
Erscheinungsdatum:2012
Publikation in MIAMI:27.02.2013
Datum der letzten Änderung:24.01.2020
Angaben zur Ausgabe:[Electronic ed.]
Quelle:Toxins 5 (2013) 1, 25-48
Schlagwörter:EspP; EHEC; virulence factor; SPATE; autotransporter; serine protease
Fachgebiet (DDC):540: Chemie
Lizenz:CC BY 3.0
Sprache:English
Anmerkungen:Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF-Dokument
URN:urn:nbn:de:hbz:6-17379538914
Weitere Identifikatoren:DOI: 10.3390/toxins5010025
Permalink:https://nbn-resolving.de/urn:nbn:de:hbz:6-17379538914
Onlinezugriff:toxins-05-00025.pdf

Enterohemorrhagic E. coli (EHEC) causes severe diseases in humans worldwide. One of its virulence factors is EspP, which belongs to the serine protease autotransporters of Enterobacteriaceae (SPATE) family. In this review we recapitulate the current data on prevalence, biogenesis, structural properties and functionality. EspP has been used to investigate mechanistic details of autotransport, and recent studies indicate that this transport mechanism is not autonomous but rather dependent on additional factors. Currently, five subtypes have been identified (EspPα-EspPε), with EspPα being associated with highly virulent EHEC serotypes and isolates from patients with severe disease. EspPα has been shown to degrade major proteins of the complement cascade, namely C3 and C5 and probably interferes with hemostasis by cleavage of coagulation factor V. Furthermore, EspPα is believed to contribute to biofilm formation perhaps by polymerization to rope-like structures. Together with the proteolytic activity, EspPα might ameliorate host colonization and interfere with host response.