Long-Term Renal Function in Liver Transplant Recipients After Conversion From Calcineurin Inhibitors to mTOR Inhibitors
BACKGROUND: Renal dysfunction often occurs in liver transplant (LT) recipients receiving calcineurin inhibitor (CNI)-based immunosuppressive regimens, increasing morbidity and mortality rates. Replacement of CNIs by mTOR inhibitor-based immunosuppressive protocols may prevent renal impairment in LT...
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FB/Einrichtung: | FB 05: Medizinische Fakultät |
Dokumenttypen: | Artikel |
Medientypen: | Text |
Erscheinungsdatum: | 2015 |
Publikation in MIAMI: | 11.01.2016 |
Datum der letzten Änderung: | 27.01.2020 |
Angaben zur Ausgabe: | [Electronic ed.] |
Quelle: | Annals of Transplantation 20 (2015), 707-713 |
Schlagwörter: | Calcineurin; Immunosuppression; Liver Transplantation; renal insufficiency; TOR Serine-Threonine Kinases |
Fachgebiet (DDC): | 610: Medizin und Gesundheit |
Lizenz: | CC BY-NC-ND 4.0 |
Sprache: | English |
Anmerkungen: | Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster). |
Format: | PDF-Dokument |
ISSN: | 2329-0358 |
URN: | urn:nbn:de:hbz:6-17229622530 |
Weitere Identifikatoren: | DOI: 10.12659/AOT.895320 |
Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-17229622530 |
Onlinezugriff: | 895320.pdf |
BACKGROUND: Renal dysfunction often occurs in liver transplant (LT) recipients receiving calcineurin inhibitor (CNI)-based immunosuppressive regimens, increasing morbidity and mortality rates. Replacement of CNIs by mTOR inhibitor-based immunosuppressive protocols may prevent renal impairment in LT recipients. MATERIAL AND METHODS: Outcomes in patients who underwent LT between 1996 and 2010 at our center and who were switched from CNI-based to mTOR inhibitor-based immunosuppression were retrospectively analyzed. Renal course, hyperlipidemia, and graft rejection were assessed in patients maintained on this CNI-free regimen for at least 24 months. RESULTS: Of the 85 patients switched from CNI-based to mTOR inhibitor-based, CNI-free immunosuppression, 78 met the inclusion criteria. Within the first 6 weeks after switching, the covariable adjusted estimated glomerular filtration rate (eGFR) increased 5.6 mL/min [95% confidence interval 2.6–8.7 mL/min, p