Development of protein loaded microparticles and nanoparticles for antigen delivery
Development of protein loaded microparticles and nanoparticles for antigen delivery
Dokument öffnen (7.2MB)Art der Hochschulschrift
DissertationPrüfungsdatum
21.11.2014Datum der Veröffentlichung
12.12.2014Erstgutachter
Lamprecht, AlfZweitgutachter
Wagner, Karl GerhardMetadaten
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Inhalt
An innovative approach of developing modern adjuvants is the design of particulate antigen delivery systems. These, typically polymeric, particles that are in a size range of micro- and nanoparticles can be used as drug carrier systems. Such drug carriers can target antigen presenting cells, which is crucial for long-lasting immunity. The aim of this work was the development and characterization of polymeric micro- and nanoparticles for the antigen delivery using biodegradable and biocompatible polymers. In this work poly(D,L-lactide-co-glycolide) (PLGA) was used as a polymer, because PLGA-microparticles and PLGA-nanoparticles already showed a potential to be used as vaccine adjuvants.
Klassifikation (DDC)
500 NaturwissenschaftenFrancis, Donny: Development of protein loaded microparticles and nanoparticles for antigen delivery. - Bonn, 2014. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5n-38473
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5n-38473
@phdthesis{handle:20.500.11811/6210,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5n-38473,
author = {{Donny Francis}},
title = {Development of protein loaded microparticles and nanoparticles for antigen delivery},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2014,
month = dec,
note = {An innovative approach of developing modern adjuvants is the design of particulate antigen delivery systems. These, typically polymeric, particles that are in a size range of micro- and nanoparticles can be used as drug carrier systems. Such drug carriers can target antigen presenting cells, which is crucial for long-lasting immunity. The aim of this work was the development and characterization of polymeric micro- and nanoparticles for the antigen delivery using biodegradable and biocompatible polymers. In this work poly(D,L-lactide-co-glycolide) (PLGA) was used as a polymer, because PLGA-microparticles and PLGA-nanoparticles already showed a potential to be used as vaccine adjuvants.},
url = {https://hdl.handle.net/20.500.11811/6210}
}
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5n-38473,
author = {{Donny Francis}},
title = {Development of protein loaded microparticles and nanoparticles for antigen delivery},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2014,
month = dec,
note = {An innovative approach of developing modern adjuvants is the design of particulate antigen delivery systems. These, typically polymeric, particles that are in a size range of micro- and nanoparticles can be used as drug carrier systems. Such drug carriers can target antigen presenting cells, which is crucial for long-lasting immunity. The aim of this work was the development and characterization of polymeric micro- and nanoparticles for the antigen delivery using biodegradable and biocompatible polymers. In this work poly(D,L-lactide-co-glycolide) (PLGA) was used as a polymer, because PLGA-microparticles and PLGA-nanoparticles already showed a potential to be used as vaccine adjuvants.},
url = {https://hdl.handle.net/20.500.11811/6210}
}
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