Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoeaImportance of co-morbidity and serum C-reactive protein
Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea
Importance of co-morbidity and serum C-reactive protein
View/Type of Scholarly Publication
DissertationDate of Exam
10.03.2010Date of Publication
08.12.2010Advisor
Dumoulin, Franz LudwigCo-Referee
Exner, MartinMetadata
Show full item record
Citable Links 
Abstract
AIM: To investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients.
METHODS: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review.
RESULTS: Severe CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, P < 0.001) and a higher proportion of longer hospital stay exceeding 14 d (74% vs 52%, P = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, P < 0.05) and serum C-reactive protein at diagnosis (OR 1.15 for 10 mg/L increment, P <0.001) were independent predictors of severe CDAD.
CONCLUSION: Patients with a severe level of comorbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention.
METHODS: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review.
RESULTS: Severe CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, P < 0.001) and a higher proportion of longer hospital stay exceeding 14 d (74% vs 52%, P = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, P < 0.05) and serum C-reactive protein at diagnosis (OR 1.15 for 10 mg/L increment, P <0.001) were independent predictors of severe CDAD.
CONCLUSION: Patients with a severe level of comorbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention.
Subjects
Clostridium difficile, nosokomiale Diarrhoe, Komorbidität, C-reaktives Protein, 30-Tage Mortalität, Nosocomial diarrhoea, Co-morbidity, C-reactive protein, 30-day mortality
Classification (DDC)
610 Medizin, GesundheitHardt, Christian: Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea : Importance of co-morbidity and serum C-reactive protein. - Bonn, 2010. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5N-21448
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5N-21448
@phdthesis{handle:20.500.11811/4325,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5N-21448,
author = {{Christian Hardt}},
title = {Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea : Importance of co-morbidity and serum C-reactive protein},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2010,
month = dec,
note = {AIM: To investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients.
METHODS: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review.
RESULTS: Severe CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, P < 0.001) and a higher proportion of longer hospital stay exceeding 14 d (74% vs 52%, P = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, P < 0.05) and serum C-reactive protein at diagnosis (OR 1.15 for 10 mg/L increment, P <0.001) were independent predictors of severe CDAD.
CONCLUSION: Patients with a severe level of comorbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention.},
url = {https://hdl.handle.net/20.500.11811/4325}
}
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5N-21448,
author = {{Christian Hardt}},
title = {Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea : Importance of co-morbidity and serum C-reactive protein},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2010,
month = dec,
note = {AIM: To investigate risk factors for severe clostridium difficile associated diarrhoea (CDAD) in hospitalised patients.
METHODS: We analysed risk factors for severe CDAD (associated with systemic signs of hypovolemia) in 124 hospitalised patients by retrospective chart review.
RESULTS: Severe CDAD was present in 27 patients (22%). Statistical analysis showed a significant association with a higher 30-d mortality (33% vs 4%, P < 0.001) and a higher proportion of longer hospital stay exceeding 14 d (74% vs 52%, P = 0.048). Charlson co-morbidity score (OR 1.29 for 1 point increment, P < 0.05) and serum C-reactive protein at diagnosis (OR 1.15 for 10 mg/L increment, P <0.001) were independent predictors of severe CDAD.
CONCLUSION: Patients with a severe level of comorbidity and high serum C-reactive protein levels at the time of diagnosis should receive particular attention.},
url = {https://hdl.handle.net/20.500.11811/4325}
}
The following license files are associated with this item:
