Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins
View/Type of Scholarly Publication
DissertationDate of Exam
10.01.2020Date of Publication
07.02.2020Advisor
Gütschow, MichaelCo-Referee
Bendas, GerdMetadata
Show full item record
Citable Links 
Abstract
The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.
Classification (DDC)
500 Naturwissenschaften 540 Chemie 610 Medizin, GesundheitBreuer, Christian: Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins. - Bonn, 2020. - Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn.
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5-57228
Online-Ausgabe in bonndoc: https://nbn-resolving.org/urn:nbn:de:hbz:5-57228
@phdthesis{handle:20.500.11811/8266,
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5-57228,
author = {{Christian Breuer}},
title = {Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2020,
month = feb,
note = {The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.},
url = {https://hdl.handle.net/20.500.11811/8266}
}
urn: https://nbn-resolving.org/urn:nbn:de:hbz:5-57228,
author = {{Christian Breuer}},
title = {Design and Synthesis of Covalent Peptidomimetic Inhibitors for Human Cysteine Cathepsins},
school = {Rheinische Friedrich-Wilhelms-Universität Bonn},
year = 2020,
month = feb,
note = {The present thesis elucidates the development of (i) a series of small molecule inhibitors reacting in a covalent-irreversible manner with the targeted proteases and (ii) a fluorescently labeled activity-based probe as a pharmacological tool compound for investigation of specific functions of the mentioned enzymes in vitro. Herein, the rational design, organic synthesis and quantitative structure-activity-relationships are described extensively.},
url = {https://hdl.handle.net/20.500.11811/8266}
}
The following license files are associated with this item:
