ER-SURF: Riding the Endoplasmic Reticulum Surface to Mitochondria
- Most mitochondrial proteins are synthesized in the cytosol and targeted to the mitochondrial surface in a post-translational manner. The surface of the endoplasmic reticulum (ER) plays an active role in this targeting reaction. ER-associated chaperones interact with certain mitochondrial membrane protein precursors and transfer them onto receptor proteins of the mitochondrial surface in a process termed ER-SURF. ATP-driven proteins in the membranes of mitochondria (Msp1, ATAD1) and the ER (Spf1, P5A-ATPase) serve as extractors for the removal of mislocalized proteins. If the re-routing to mitochondria fails, precursors can be degraded by ER or mitochondria-associated degradation (ERAD or MAD respectively) in a proteasome-mediated reaction. This review summarizes the current knowledge about the cooperation of the ER and mitochondria in the targeting and quality control of mitochondrial precursor proteins.
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| Author: | Christian KochORCiD, Maya SchuldinerORCiD, Johannes M. Herrmann |
|---|---|
| URN: | urn:nbn:de:hbz:386-kluedo-66078 |
| ISSN: | 1422-0067 |
| Parent Title (English): | International Journal of Molecular Sciences |
| Document Type: | Review |
| Language of publication: | English |
| Date of Publication (online): | 2021/09/06 |
| Year of first Publication: | 2021 |
| Publishing Institution: | Technische Universität Kaiserslautern |
| Date of the Publication (Server): | 2021/10/06 |
| Issue: | 2021, 22(17) |
| Page Number: | 13 |
| Source: | https://doi.org/10.3390/ijms22179655 |
| Faculties / Organisational entities: | Kaiserslautern - Fachbereich Biologie |
| DDC-Cassification: | 5 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie |
| Collections: | Open-Access-Publikationsfonds |
| Licence (German): | Zweitveröffentlichung |