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Cerebral venous sinus thrombosis after ChAdOx1 nCov-19 vaccination with a misleading first cerebral MRI scan
- Vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) have been recently described as rare complications following vaccination against SARS-CoV-2 with vector vaccines. We report a case of a young woman who presented with VITT and cerebral CVST 7 days following vaccination with ChAdOx1 nCov-19 (AstraZeneca). While the initial MRI was considered void of pathological findings, MRI 3 days later revealed extensive CVST of the transversal and sigmoidal sinus with intracerebral haemorrhage. Diagnostic tests including a platelet-factor-4-induced platelet activation assay confirmed the diagnosis of VITT. Treatment with intravenous immunoglobulins and argatroban resulted in a normalisation of platelet counts and remission of CVST.
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| Author: | Benno Ikenberg, Antonia Franziska Demleitner, Thomas Thiele, Benedikt Wiestler, Katharina Götze, Georg Mößmer, Paul Lingor |
|---|---|
| URN: | urn:nbn:de:gbv:9-opus-58530 |
| DOI: | https://doi.org/10.1136/svn-2021-001095 |
| ISSN: | 2059-8696 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/34244448 |
| Parent Title (English): | Stroke and Vascular Neurology |
| Publisher: | BMJ Publishing Group Ltd |
| Place of publication: | London |
| Document Type: | Article |
| Language: | English |
| Year of first Publication: | 2021 |
| Release Date: | 2022/07/06 |
| Tag: | COVID-19; MRI; blood platelets; complication; haemorrhage |
| GND Keyword: | - |
| Volume: | 6 |
| Page Number: | 3 |
| First Page: | 668 |
| Last Page: | 670 |
| Faculties: | Universitätsmedizin / Institut für Immunologie u. Transfusionsmedizin - Abteilung Transfusionsmedizin |
| Licence (German): |  Creative Commons - Namensnennung-Nicht kommerziell |