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Gemcitabine and Docetaxel for Epithelioid Sarcoma: Results from a Retrospective, Multi-Institutional Analysis

  • Objective: Epithelioid sarcoma (ES) presents unique clinical features in comparison to other sarcoma subtypes. Data regarding the benefits of chemotherapy are very limited. Combination regimens using gemcitabine and docetaxel (Gem/Doce) have proven to be effective, especially in uterine and nonuterine leiomyosarcoma. Yet, there is no available data on the efficacy of Gem/Doce in ES. Methods: A retrospective analysis of the three participating institutions was performed. Twenty-eight patients with an ES diagnosis presented at one of the participating institutions between 1989 and 2012. Of this group, 17 patients received chemotherapy. Results: Patients' median overall survival (OS) after the beginning of palliative chemotherapy was 21 months, and the 1-year OS was 87%. Twelve patients received Gem/Doce with a clinical benefit rate of 83%. The median progression-free survival (PFS) was 8 months for all patients receiving Gem/Doce. The best response was complete remission in 1 patient and partial remission in 6 patients. All 6 patients receiving Gem/Doce as a first-line treatment showed measurable responses with a median PFS of 9 months. Conclusions: In this retrospective study, Gem/Doce was an effective chemotherapeutic regimen for ES. Prospective studies are needed to better assess the effects of this combination drug therapy.

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Metadaten
Author: Daniel Pink, Stephan Richter, Sebastian Gerdes, Dimosthenis Andreou, Per-Ulf Tunn, Christoph Busemann, Gerhard Ehninger, Peter Reichardt, Markus K. Schuler
URN:urn:nbn:de:gbv:9-opus-31068
URL:http://www.karger.com/ocl
DOI:https://doi.org/10.1159/000362602
ISSN:0030-2414
ISSN:1423-0232
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/25011671
Parent Title (English):Oncology
Publisher:S. Karger AG
Place of publication:Basel, Switzerland
Document Type:Article
Language:English
Date of first Publication:2014/07/04
Release Date:2020/09/29
Tag:Chemotherapy; Combination chemotherapy; Docetaxel; Epithelioid sarcoma; Gemcitabine; Palliative chemotherapy; Sarcoma; Soft tissue sarcoma
GND Keyword:-
Volume:87
Issue:2
First Page:95
Last Page:103
Faculties:Universitätsmedizin / Kliniken und Polikliniken für Innere Medizin
Licence (German):License LogoUrheberrechtlich geschützt