Crohn's-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d
In the recent study by Rosati et al, we described a novel unconventional T cell population enriched in the peripheral blood of patients with Crohn’s disease (CD) and characterised by a semi- invariant Tcell receptor (TCR) repertoire. 1 However, the specificity of these Crohn’s- associated invariant T (CAIT) cells was not defined.
Identifying the specificity of CAIT cells is essential to understand the origin of the antigen triggering their enrichment in CD.
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Minervina, A.A., Pogorelyy, M.V., Paysen, S., Luening, U., Degenhardt, F., Franke, A., Thomas, P.G., Rosati, E., 2023. Crohn’s-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d. Gut 73, 205–206. https://doi.org/10.1136/gutjnl-2022-328684
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