Die Prion-Protein-Isoformen
Prion protein isoforms
von Katharina Schwarzbach geb. Lüllmann
Datum der mündl. Prüfung:2016-09-27
Erschienen:2016-09-20
Betreuer:Prof. Dr. Inga Zerr
Gutachter:Prof. Dr. Hassan Dihazi
Gutachter:Prof. Dr. Martin Oppermann
Dateien
Name:schwarzbach_dissertation.pdf
Size:2.95Mb
Format:PDF
Zusammenfassung
Englisch
We performed two-dimensional immunoblotting of prion protein charge isomers of PrPC from human CSF of CJD patients with sporadic and familial CJD and control patients with distinct codon 129 polymorphism or different prion strains. Densitometric quantification of the prion isoform charge isomers revealed subtile different isoform expression depending on the codon 129 polymorphism, prion strain or CJD form.
Keywords: prion
Schlagwörter: Prion, Codon 129 Polymorphismus