Chiral separation in microflows
- Molecules that only differ by their chirality, so called enantiomers, often possess different properties with respect to their biological function. Therefore, the separation of enantiomers presents a prominent challenge in molecular biology and belongs to the ``Holy Grail'' of organic chemistry. We suggest a new separation technique for chiral molecules that is based on the transport properties in a microfluidic flow with spatially variable vorticity. Because of their size the thermal fluctuating motion of the molecules must be taken into account. These fluctuations play a decisive role in the proposed separation mechanism.
| Author: | Marcin KosturGND, Michael SchindlerGND, Peter TalknerGND, Peter HänggiORCiDGND |
|---|---|
| URN: | urn:nbn:de:bvb:384-opus4-2679 |
| Frontdoor URL | https://opus.bibliothek.uni-augsburg.de/opus4/333 |
| Type: | Preprint |
| Language: | English |
| Publishing Institution: | Universität Augsburg |
| Release Date: | 2006/08/31 |
| Tag: | separation; chirality; isomerism; molecular biophysics; microfluidics; vortices; fluctuations |
| GND-Keyword: | Chiralität <Elementarteilchenphysik>; Isomer; Molekulare Biophysik; Trennverfahren |
| Source: | erschienen in: Phys. Rev. Lett. 96, 014502 (2006); DOI: 10.1103/PhysRevLett.96.014502; URL: http://link.aps.org/abstract/PRL/v96/e014502 |
| Institutes: | Mathematisch-Naturwissenschaftlich-Technische Fakultät |
| Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik | |
| Mathematisch-Naturwissenschaftlich-Technische Fakultät / Institut für Physik / Lehrstuhl für Theoretische Physik I | |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
