Investigation of the HelioVital filter foil revealed protective effects against UVA1 irradiation-induced DNA damage and against UVA1-induced expression of matrixmetalloproteinases (MMP) MMP1, MMP2, MMP3 and MMP15

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-517198 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.51719 Copy

Ivanova, I. ; Kurz, B. ; Lang, K. ; Maisch, T. ; Berneburg, M. ; Kamenisch, Y.

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Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (1MB)

Veröffentlichungsdatum dieses Volltextes: 22 Feb 2022 10:36

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Diese Publikation ist Teil des DEAL-Vertrags mit Springer.

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Details

Dokumentenart:	Artikel
Open Access Art:	DEAL (Springer)
Titel eines Journals oder einer Zeitschrift:	Photochemical & Photobiological Sciences
Verlag:	SPRINGERNATURE
Ort der Veröffentlichung:	LONDON
Datum:	16 Februar 2022
Institutionen:	Medizin > Lehrstuhl für Dermatologie und Venerologie
Projekte:	HelioVital GmbH
Identifikationsnummer:	Wert Typ 10.1007/s43630-022-00177-4 DOI
Stichwörter / Keywords:	MATRIX METALLOPROTEINASES; ULTRAVIOLET-RADIATION; PHOTODYNAMIC THERAPY; ACTINIC KERATOSES; SKIN; GUIDELINES; HELIOTHERAPY; FIBROBLASTS; GENERATION; PSORIASIS; Ultraviolet (UV) radiation; UVA1; HelioVital filter foil; Reactive oxygen species; MMP
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Zum Teil
Dokumenten-ID:	51719

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Zusammenfassung

The damaging effects of solar ultraviolet (UV) radiation exposure to human skin are well known and can reach from accelerated skin aging (photoaging) to skin cancer. Much of the damaging effects of solar UVA (320-400 nm) radiation is associated with the induction of reactive oxygen species (ROS), which are capable to cause oxidative damage to DNA like the oxidized guanosine 8-hydroxy-2' ...

Zusammenfassung

The damaging effects of solar ultraviolet (UV) radiation exposure to human skin are well known and can reach from accelerated skin aging (photoaging) to skin cancer. Much of the damaging effects of solar UVA (320-400 nm) radiation is associated with the induction of reactive oxygen species (ROS), which are capable to cause oxidative damage to DNA like the oxidized guanosine 8-hydroxy-2' -deoxyguanosine (8-OHdG). Therefore, new UV protective strategies, have to be tested for their efficiency to shield against UV induced damage. We investigated the protective effects of HelioVital sun protection filter foil against UVA1 irradiation in skin cells. It could be shown, that HelioVital sun protection filter foil has protective effects against UVA1 irradiation induced changes in matrix metalloproteinase (MMP) expression. Furthermore a UVA1-dependant regulation of MMP15 in human fibroblasts could be shown for the first time in this context. In addition, this study demonstrated the protective effect of the HelioVital filter film against UVA1-induced ROS production and DNA damage. These results could pave the way for clinical studies with HelioVital filter foil shielding against the damaging effects of phototherapy and other forms of irradiation therapy, thereby increasing the safety and treatment opportunities of these forms of therapy. [GRAPHICS] .

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Metadaten zuletzt geändert: 26 Jan 2023 15:29

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