Post-transplant multimorbidity index and quality of life in patients with chronic graft-versus-host disease—results from a joint evaluation of a prospective German multicenter validation trial and a cohort from the National Institutes of Health

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-452271 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.45227 Copy

Wolff, Daniel ; Herzberg, Philipp Y. ; Herrmann, Anne ; Pavletic, Steven Z. ; Heussner, Pia ; Mumm, Friederike ; Höfer, Christina ; Hilgendorf, Inken ; Hemmati, Philipp G. ; Holler, Ernst ; Greinix, Hildegard ;

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Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (746kB)

Veröffentlichungsdatum dieses Volltextes: 18 Mrz 2021 06:38

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Diese Publikation ist Teil des DEAL-Vertrags mit Springer.

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Details

Dokumentenart:	Artikel
Open Access Art:	DEAL (Springer)
Titel eines Journals oder einer Zeitschrift:	Bone Marrow Transplantation
Verlag:	SPRINGERNATURE
Ort der Veröffentlichung:	LONDON
Band:	56
Seitenbereich:	S. 243-256
Datum:	31 Juli 2020
Institutionen:	Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Projekte:	Else Kröner Fresenius Stiftung
Identifikationsnummer:	Wert Typ 10.1038/s41409-020-01017-8 Nicht ausgewählt
Stichwörter / Keywords:	HEMATOPOIETIC-CELL TRANSPLANTATION; LONG-TERM SURVIVORS; BONE-MARROW-TRANSPLANTATION; CONSENSUS DEVELOPMENT PROJECT; COMORBIDITY INDEX; CLINICAL-PRACTICE; ALLOGENEIC TRANSPLANTATION; INTERNATIONAL-BLOOD; FUNCTIONAL STATUS; APLASTIC-ANEMIA;
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Zum Teil
Dokumenten-ID:	45227

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Zusammenfassung

Comorbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT) impairs quality of life (QoL), physical functioning, and survival. We developed a new standardized measure to capture comorbidity after transplantation, the Post-transplant Multimorbidity Index (PTMI) in a cohort of 50 long term survivors. We subsequently evaluated the content validity and impact on survival and QoL ...

Zusammenfassung

Comorbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT) impairs quality of life (QoL), physical functioning, and survival. We developed a new standardized measure to capture comorbidity after transplantation, the Post-transplant Multimorbidity Index (PTMI) in a cohort of 50 long term survivors. We subsequently evaluated the content validity and impact on survival and QoL within a multicenter trial, including 208 patients (pts) after alloHSCT, who were prospectively evaluated applying the FACT-BMT, the Human Activity Profile (HAP), the SF-36 v.2, PTMI and the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI). The most prevalent comorbidities were compensated arterial hypertension (28.4%), ambulatory infections (25.5%), iron overload (23%), mild renal function impairment (20%), and osteoporosis (13%). Applying the PTMI 13% of patients had no comorbidity, while 37.1% had 1-3 comorbidities, 27.4% had 4-6 comorbidities, and 13.5% had > 6 comorbidities. Chronic graft-versus-host disease (cGvHD) was significantly associated with the PTMI, while age and prior acute GvHD were not. In contrast, the HCT-CI was not associated with the presence of cGvHD. cGvHD was significantly associated with depression (r = 0.16), neurological disease (r = 0.21), osteoporosis (r = 0.18) and nonmelanoma skin cancer (r = 0.26). The PTMI demonstrated strong measurement properties and compared to the HCT-CI captured a wider range of comorbidities associated with cGvHD.

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