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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-407807
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.40780
Zusammenfassung
Objective: Human mouse double minute 2 (Mdm2) is essential in degrading p53 by acting as an ubiquitin ligase and therefore plays a vital role in cell cycle and survival. The G-variant of the Mdm2 SNP309, which is located within the promoter of the Mdm2 gene, increases expression of Mdm2 and thereby inhibits the p53 pathway. Several studies have investigated the influence of this SNP on disease ...
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