Lizenz: Allianz- bzw. Nationallizenz PDF - Veröffentlichte Version (195kB) |
- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-376387
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.37638
Zusammenfassung
With this letter to the editor we present for the first time a study on CHEK2 expression in normal urothelium of healthy male smokers, former smokers and non-smokers. We could show a statistically significant downregulation of this DNA repair gene in current smokers compared to non-smokers, suggesting that smoking downregulates CHEK2 in normal urothelium, probably associated with an early step in carcinogenesis of urothelial bladder carcinoma. (C) 2016 S. Karger AG, Basel