The main barriers to the wide acceptance of electric vehicles, such as the limited driving range or the high acquisition costs, are to be countered by various technology alternatives for the powertrain of the future. Promising developments include improved battery technologies, fuel cell technologies or a constant power supply of the vehicle while driving, for example through dynamic inductive charging. In this context, a holistic technology comparison would contribute to a comprehensive and understandable information situation by making the heterogeneous technological concepts comparable with regard to different evaluation criteria. Therefore, this work describes the basic assumptions of the proposed holistic comparison of alternative powertrain technologies for long-distance mobility. Relevant framework conditions are structured and a procedure for the evaluation of infrastructure expenditures is shown. Building on this, a selection of key performance indicators is defined and explained. The proposed KPI framework is applied to a passenger car in the economic area Germany. The results show that by using electrified roadways, ecological as well as economic advantages against other alternative powertrain designs can be derived.