Modulation of host signaling and cellular responses by Chlamydia

Please always quote using this URN: urn:nbn:de:bvb:20-opus-97225
  • Modulation of host cell signaling and cellular functions is key to intracellular survival of pathogenic bacteria. Intracellular growth has several advantages e.g. escape from the humoral immune response and access to a stable nutrient rich environment. Growth in such a preferred niche comes at the price of an ongoing competition between the bacteria and the host as well as other microbes that compete for the very same host resources. This requires specialization and constant evolution of dedicated systems for adhesion, invasion andModulation of host cell signaling and cellular functions is key to intracellular survival of pathogenic bacteria. Intracellular growth has several advantages e.g. escape from the humoral immune response and access to a stable nutrient rich environment. Growth in such a preferred niche comes at the price of an ongoing competition between the bacteria and the host as well as other microbes that compete for the very same host resources. This requires specialization and constant evolution of dedicated systems for adhesion, invasion and accommodation. Interestingly, obligate intracellular bacteria of the order Chlamydiales have evolved an impressive degree of control over several important host cell functions. In this review we summarize how Chlamydia controls its host cell with a special focus on signal transduction and cellular modulation.show moreshow less

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Metadaten
Author: Thomas Rudel, Adrian Mehlitz
URN:urn:nbn:de:bvb:20-opus-97225
Document Type:Journal article
Faculties:Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Cell Communication and Signaling
Year of Completion:2013
Source:In: Cell Communication and Signaling (2013) 11: 90, doi:10.1186/1478-811X-11-90
URL:http://www.biosignaling.com/content/11/1/90
DOI:https://doi.org/10.1186/1478-811X-11-90
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Tag:Chlamydia; Inc; Inclusion; Invasion; Signaling; Tarp; Trafficking; Type III secretion
Release Date:2014/05/07
Collections:Open-Access-Publikationsfonds / Förderzeitraum 2013
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung